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Sodium Iodoacetate

Name: Sodium Iodoacetate
Brand: TargetMol
SKU: T87414
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T87414Cas No. 305-53-3

Alias Iodoacetic Acid Sodium Salt

Sodium Iodoacetate is a specific and irreversible inhibitor of GAPDH that suppresses glycolysis. It is commonly employed to establish osteoarthritis models.

Sodium Iodoacetate

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Purity: 97.07%

Catalog No. T87414Alias Iodoacetic Acid Sodium SaltCas No. 305-53-3

Sodium Iodoacetate is a specific and irreversible inhibitor of GAPDH that suppresses glycolysis. It is commonly employed to establish osteoarthritis models.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	-	In Stock
5 g	$48	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.07%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Sodium Iodoacetate is a specific and irreversible inhibitor of GAPDH that suppresses glycolysis. It is commonly employed to establish osteoarthritis models.
In vivo	A single injection of Sodium Iodoacetate (0, 0.3, and 3 mg/joint) into the right knee joint space induced synovial cell proliferation and moderate fibrotic changes in Wistar rats, accompanied by mild inflammatory cell infiltration [3].
Synonyms	Iodoacetic Acid Sodium Salt

Chemical Properties

Molecular Weight	207.93
Formula	C₂H₂INaO₂
Cas No.	305-53-3
Smiles	O=C(CI)[O-].[Na+]

Storage & Solubility Information

Storage

store at low temperature,store under nitrogen | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 80 mg/mL (384.74 mM), Sonication is recommended.

H2O: ≥ 80 mg/mL, Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.8093 mL	24.0466 mL	48.0931 mL	240.4655 mL
5 mM	0.9619 mL	4.8093 mL	9.6186 mL	48.0931 mL
10 mM	0.4809 mL	2.4047 mL	4.8093 mL	24.0466 mL
20 mM	0.2405 mL	1.2023 mL	2.4047 mL	12.0233 mL
50 mM	0.0962 mL	0.4809 mL	0.9619 mL	4.8093 mL
100 mM	0.0481 mL	0.2405 mL	0.4809 mL	2.4047 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc