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Dicyclomine hydrochloride

Name: Dicyclomine hydrochloride
Brand: TargetMol
SKU: T1460
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1460Cas No. 67-92-5

Dicyclomine hydrochloride is a muscarinic antagonist used as an antispasmodic and in urinary incontinence.

Dicyclomine hydrochloride

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Purity: 99.81%

Catalog No. T1460Cas No. 67-92-5

Dicyclomine hydrochloride is a muscarinic antagonist used as an antispasmodic and in urinary incontinence.

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$30	In Stock	In Stock
500 mg	$40	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.81%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Dicyclomine hydrochloride AI Summary

Dicyclomine hydrochloride exhibits a wide range of bioactivities. It shows antiplasmodial activity against various strains of Plasmodium falciparum, with IC50 values ranging from 5011.87 nM to 15848.93 nM as determined by the SYBR green assay over 72 hours. Additionally, it inhibits the proliferation of various Plasmodium falciparum lines, displaying potency in various biological processes including the ERK signaling pathway, Neuropeptide S receptor, and entry or binding of Lassa and Marburg Viruses. The compound also demonstrates potent inhibition of sodium fluorescein uptake in OATP1B3- and OATP1B1-transfected CHO cells, with inhibition percentages over 100% at 10 µM. Moreover, Dicyclomine hydrochloride shows antibiofilm activity against Candida albicans with an MBIC50 value of 60.0 µM. It has limited inhibition of SARS-CoV-2 in Vero E6 cells and Caco-2 cells, displaying low percentages of viral cytotoxicity inhibition and weak inhibition of the SARS-CoV-2 3CL-Pro protease. The compound also displays various degrees of antifungal and antibacterial activities, including: - Candida albicans ATCC 90028: 3.82% inhibition - Cryptococcus neoformans H99 ATCC 208821: -0.13% inhibition - Escherichia coli ATCC 25922: 0.37% inhibition - Klebsiella pneumoniae MDR ATCC 70063: 5.74% inhibition - Pseudomonas aeruginosa ATCC 27853: 3.37% inhibition - Acinetobacter baumannii ATCC 19606: 27.79% inhibition - Staphylococcus aureus MRSA ATCC 43300: 8.61% inhibition Overall, Dicyclomine hydrochloride demonstrates a multifaceted bioactivity profile with noteworthy antiparasitic, antiviral, and antibacterial properties..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Dicyclomine hydrochloride is a muscarinic antagonist used as an antispasmodic and in urinary incontinence.
Targets&IC50	M1 mAChR (brush-border membrane):5.1 nM (Ki)

Chemical Properties

Molecular Weight	345.95
Formula	C₁₉H₃₆ClNO₂
Cas No.	67-92-5
Smiles	Cl.CCN(CC)CCOC(=O)C1(CCCCC1)C1CCCCC1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 199.5 mM, Sonication is recommended.

DMSO: 60 mg/mL (173.44 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.78 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.8906 mL	14.4530 mL	28.9059 mL	144.5296 mL
5 mM	0.5781 mL	2.8906 mL	5.7812 mL	28.9059 mL
10 mM	0.2891 mL	1.4453 mL	2.8906 mL	14.4530 mL
20 mM	0.1445 mL	0.7226 mL	1.4453 mL	7.2265 mL
50 mM	0.0578 mL	0.2891 mL	0.5781 mL	2.8906 mL
100 mM	0.0289 mL	0.1445 mL	0.2891 mL	1.4453 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc