keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DC432 is a cell-permeable peptide that serves as an inhibitor of N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1; IC50 = 0.054 µM), capable of binding to both NTMT1 and NTMT2 with dissociation constants (Kds) of 0.3 and 1 µM, respectively. It effectively inhibits the N-terminal dimethylation of regulator of chromosome condensation 1 (RCC1) by NTMT1 at concentrations of 10 and 50 µM in cell-free assays. Furthermore, at a concentration of 100 µM, DC432 diminishes the trimethylation of the RCC1 SPKRIA motif in HCT116 cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | Inquiry | $ 84.00 | |
5 mg | Inquiry | $ 397.00 | |
10 mg | Inquiry | $ 754.00 | |
25 mg | Inquiry | $ 1,770.00 |
Description | DC432 is a cell-permeable peptide that serves as an inhibitor of N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1; IC50 = 0.054 µM), capable of binding to both NTMT1 and NTMT2 with dissociation constants (Kds) of 0.3 and 1 µM, respectively. It effectively inhibits the N-terminal dimethylation of regulator of chromosome condensation 1 (RCC1) by NTMT1 at concentrations of 10 and 50 µM in cell-free assays. Furthermore, at a concentration of 100 µM, DC432 diminishes the trimethylation of the RCC1 SPKRIA motif in HCT116 cells. |
Molecular Weight | 1313.60 |
Formula | C55H100N28O10.XCF3COOH |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMF: 10 mg/ml
Ethanol: 2 mg/ml
DMSO: 10 mg/ml
PBS pH 7.2: 2 mg/ml
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.