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Anti-CDKN1B/p27 KIP 1 Antibody (6O767)
Catalog No. TMAB-04178 Copy Product Info
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Anti-CDKN1B/p27 KIP 1 Antibody (6O767) is a Mouse antibody targeting CDKN1B/p27 KIP 1. Anti-CDKN1B/p27 KIP 1 Antibody (6O767) can be used in IHC-P,IHC-Fr,IF.
Anti-CDKN1B/p27 KIP 1 Antibody (6O767)
Copy Product Info🥰Excellent
Catalog No. TMAB-04178
Anti-CDKN1B/p27 KIP 1 Antibody (6O767) is a Mouse antibody targeting CDKN1B/p27 KIP 1. Anti-CDKN1B/p27 KIP 1 Antibody (6O767) can be used in IHC-P,IHC-Fr,IF.
Anti-CDKN1B/p27 KIP 1 Antibody
(6O767)
(6O767)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $223 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-CDKN1B/p27 KIP 1 Antibody (6O767) is a Mouse antibody targeting CDKN1B/p27 KIP 1. Anti-CDKN1B/p27 KIP 1 Antibody (6O767) can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG1 |
| Clone | 6O767 |
| Reactivity | Human |
| Verified Activity | Paraformaldehyde-fixed, paraffin embedded (human brain glioma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30 min; Incubation with (CDKN1B/p27 KIP 1) Monoclonal Antibody, Unconjugated (TMAB-04178) at 1: 200 overnight at 4°C, followed by operating according to SP Kit (Mouse) instructions and DAB staining. |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Subcellular Localization | Nucleus. Cytoplasm. Endosome. Note=Nuclear and cytoplasmic in quiescent cells. AKT-or RSK-mediated phosphorylation on Thr-198, binds 14-3-3, translocates to the cytoplasm and promotes cell cycle progression. Mitogen-activated UHMK1 phosphorylation on Ser-10 also results in translocation to the cytoplasm and cell cycle progression. Phosphorylation on Ser-10 facilitates nuclear export. Translocates to the nucleus on phosphorylation of Tyr-88 and Tyr-89. Colocalizes at the endosome with SNX6; this leads to lysosomal degradation. |
| Tissue Specificity | Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney. |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Cell cycle progression is regulated by cyclins and their cognate Cdks. p27 KIP 1 is a cell cycle regulatory mitotic inhibitor of cdk activity. p27 KIP 1 is a candidate tumor suppressor gene, and has been proposed to function as a possible mediator of TGF beta induced G1 arrest. p27 KIP 1 is up regulated in response to antimitogenic stimuli. The increased protein expression of p27 results in cellular arrest by binding to cyclin/Cdk complexes such as cyclin D1/Cdk4. p27 Kip1 is regulated by phosphorylation on serine 10 (S10) and threonine 187 (T187). Phosphorylation by CDK2 on T187 results in ubiquitylation and degradation of p27 Kip 1; while phosphorylation by hKIS on S10 signals the nuclear export to the cytoplasm. |
| Immunogen | Recombinant Protein: human CDKN1B |
| Antigen Species | Human |
| Gene Name | CDKN1B |
| Gene ID | |
| Protein Name | Cyclin-dependent kinase inhibitor 1B |
| Uniprot ID | |
| Function | Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. |
| Molecular Weight | Theoretical: 22 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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