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TUG-891

Name: TUG-891
Brand: TargetMol
SKU: T3433
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3433Cas No. 1374516-07-0

Alias TUG891, TUG 891

TUG-891 is a G protein-coupled receptor (GPCR) expressed in intestine, adipocytes, and pro-inflammatory macrophages that is activated by long chain free fatty acids.

TUG-891

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Purity: 99.21%

Catalog No. T3433Alias TUG891, TUG 891Cas No. 1374516-07-0

TUG-891 is a G protein-coupled receptor (GPCR) expressed in intestine, adipocytes, and pro-inflammatory macrophages that is activated by long chain free fatty acids.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$34	In Stock	In Stock
2 mg	$47	In Stock	In Stock
5 mg	$77	In Stock	In Stock
10 mg	$117	In Stock	In Stock
25 mg	$237	In Stock	In Stock
50 mg	$397	In Stock	In Stock
100 mg	$582	-	In Stock
500 mg	$1,230	-	In Stock
1 mL x 10 mM (in DMSO)	$85	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.21%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	TUG-891 is a G protein-coupled receptor (GPCR) expressed in intestine, adipocytes, and pro-inflammatory macrophages that is activated by long chain free fatty acids.
In vitro	TUG-891 exhibits analogous signaling characteristics to the long-chain fatty acid (LCFA) α-linolenic acid at the human Free Fatty Acid receptor 4 (FFA4), stimulating Ca2+ mobilization, recruiting β-arrestin-1 and β-arrestin-2, and promoting extracellular signal-regulated kinase phosphorylation. Moreover, TUG-891 activation of FFA4 leads to the receptor's swift phosphorylation and internalization[1].
Kinase Assay	Inhibition of recombinant human Mps1 by BAY 1161909 or BAY 1217389 is assessed in TRFRET-based in vitro kinase assays via phosphorylation of a biotinylated peptide (Biotin-Ahx-PWDPDDADITEILG-NH2). Under standard assay conditions kinase and test compound are preincubated for 15 min before enzyme reaction is started by addition of substrate and ATP upon 10 μM[1].
Synonyms	TUG891, TUG 891

Chemical Properties

Molecular Weight	364.41
Formula	C₂₃H₂₁FO₃
Cas No.	1374516-07-0
Smiles	C(OC1=CC=C(CCC(O)=O)C=C1)C2=C(C=CC(F)=C2)C3=CC=C(C)C=C3
Relative Density.	1.199 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (686.04 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.49 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7442 mL	13.7208 mL	27.4416 mL	137.2081 mL
5 mM	0.5488 mL	2.7442 mL	5.4883 mL	27.4416 mL
10 mM	0.2744 mL	1.3721 mL	2.7442 mL	13.7208 mL
20 mM	0.1372 mL	0.6860 mL	1.3721 mL	6.8604 mL
50 mM	0.0549 mL	0.2744 mL	0.5488 mL	2.7442 mL
100 mM	0.0274 mL	0.1372 mL	0.2744 mL	1.3721 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc