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Anti-SKP1 Antibody (1B386)
Catalog No. TMAB-12828 Copy Product Info
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Anti-SKP1 Antibody (1B386) is a Rabbit antibody targeting SKP1. Anti-SKP1 Antibody (1B386) can be used in FCM, ICC/IF, WB.
Anti-SKP1 Antibody (1B386)
Copy Product Info🥰Excellent
Catalog No. TMAB-12828
Anti-SKP1 Antibody (1B386) is a Rabbit antibody targeting SKP1. Anti-SKP1 Antibody (1B386) can be used in FCM, ICC/IF, WB.
Anti-SKP1 Antibody
(1B386)
(1B386)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 25 μL | $148 | 7-10 days | 7-10 days | |
| 50 μL | $264 | 7-10 days | 7-10 days | |
| 100 μL | $472 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
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| Description | Anti-SKP1 Antibody (1B386) is a Rabbit antibody targeting SKP1. Anti-SKP1 Antibody (1B386) can be used in FCM, ICC/IF, WB. |
| Ig Type | IgG |
| Clone | 1B386 |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | 25 ug total protein per lane of various lysates (see on figure) probed with SKP1 monoclonal antibody, unconjugated (TMAB-12828) at 1: 1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r. T. for 60 min. |
| Application | |
| Recommended Dose | FCM=1:50-100; ICC/IF=1:50-200; WB=1:500-2000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| Research Background | Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5, CEP68 and probably NFKB2. |
| Immunogen | A synthesized peptide: human SKP1 |
| Antigen Species | Human |
| Gene Name | SKP1 |
| Gene ID | |
| Protein Name | S-phase kinase-associated protein 1 |
| Uniprot ID | |
| Function | Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(Cyclin F) directs ubiquitination of CP110. |
| Molecular Weight | Theoretical: 19 kDa. Actual: 19 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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