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N-Lauroylsarcosine

Name: N-Lauroylsarcosine
Brand: TargetMol
SKU: T65365
Rating: 4.5 (1 reviews)

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Catalog No. T65365Cas No. 97-78-9

N-Lauroylsarcosine is an amphiphilic anionic surfactant derived from sarcosine , commonly used as a foaming agent and detergent for the preparation of ph-sensitive vesicles and micellar aggregates with antiviral activity against HSV.

N-Lauroylsarcosine

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Catalog No. T65365Cas No. 97-78-9

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Product Introduction

Bioactivity

Description	N-Lauroylsarcosine is an amphiphilic anionic surfactant derived from sarcosine , commonly used as a foaming agent and detergent for the preparation of ph-sensitive vesicles and micellar aggregates with antiviral activity against HSV.
Targets&IC50	HSV2 (strain 333) infectivity (cultured cells):225.30 μM (ID₉₀), HSV2 (strain 333) infectivity (cultured cells):141.76 μM (ID₅₀)
In vitro	N-Lauroylsarcosine (LS) effectively inhibited HSV-2 (strain 333) infectivity in cultured cells, with 50% and 90% inhibitory concentrations (ID₅₀ and ID₉₀) of 141.76 μM and 225.30 μM, respectively, indicating strong antiviral activity[1].
In vivo	In a murine intravaginal HSV-2 infection model, pretreatment with a 2.5% N-Lauroylsarcosine thermoreversible gel completely prevented infection, with no symptoms or detectable virus in vaginal tissues[1].

Chemical Properties

Molecular Weight	271.4
Formula	C₁₅H₂₉NO₃
Cas No.	97-78-9
Smiles	O=C(O)CN(C(=O)CCCCCCCCCCC)C

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: < 1 mg/mL (insoluble)

DMSO: 180 mg/mL (663.23 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6846 mL	18.4230 mL	36.8460 mL	184.2299 mL
5 mM	0.7369 mL	3.6846 mL	7.3692 mL	36.8460 mL
10 mM	0.3685 mL	1.8423 mL	3.6846 mL	18.4230 mL
20 mM	0.1842 mL	0.9211 mL	1.8423 mL	9.2115 mL
50 mM	0.0737 mL	0.3685 mL	0.7369 mL	3.6846 mL
100 mM	0.0368 mL	0.1842 mL	0.3685 mL	1.8423 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc