HER2/ERBB2 Protein, Human, Recombinant (GST)

Catalog No. TMPC-00263 Copy Product Info

HER2/ERBB2 Protein, Human, Recombinant (GST) is expressed in Baculovirus-Insect Cells. The accession number is P04626.

HER2/ERBB2 Protein, Human, Recombinant (GST)

Catalog No. TMPC-00263

Copy Product Info

HER2/ERBB2 Protein, Human, Recombinant (GST) is expressed in Baculovirus-Insect Cells. The accession number is P04626.

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10 μg	$1,390	Inquiry	Inquiry

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Biological Activity	The specific activity of HER2 was determined to be 3.6-3.9 nmol/min/mg by ADP-Glo kinase assay.
Description	HER2/ERBB2 Protein, Human, Recombinant (GST) is expressed in Baculovirus-Insect Cells. The accession number is P04626.
Species	Human
Expression System	Baculovirus-Insect Cells
Tag	N-GST
Accession Number	P04626
Synonyms	Receptor tyrosine-protein kinase erbB-2,NGL,NEU,MLN19,MLN 19,HER2,ERBB2
Construction	Recombinant human HER2 (676-end) was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Protein Purity	>70% as determined by SDS-PAGE.
Molecular Weight	~115 kDa
Formulation	Supplied as sterile 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	Enzymes are highly recommended to be shipped at frozen temperature with dry ice. Shipment made at ambient temperature may seriously affect the activity of the ordered products.
Research Background	Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy