CBP/p300-IN-5

Name: CBP/p300-IN-5
Brand: TargetMol
SKU: T12346
Rating: 4.5 (1 reviews)

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Catalog No. T12346Cas No. 1889284-33-6

Alias P300/CBP-IN-5

P300/CBP-IN-5 is a potent inhibitor of p300/CBP histone acetyltransferase (IC50 of 18.8 nM).

CBP/p300-IN-5

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Catalog No. T12346Alias P300/CBP-IN-5Cas No. 1889284-33-6

P300/CBP-IN-5 is a potent inhibitor of p300/CBP histone acetyltransferase (IC50 of 18.8 nM).

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	Inquiry	35 days	35 days

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Product Introduction

Bioactivity

Description	P300/CBP-IN-5 is a potent inhibitor of p300/CBP histone acetyltransferase (IC50 of 18.8 nM).
Targets&IC50	p300/CBP:18.8 nM
In vitro	P300/CBP-IN-5 inhibits H3K27Ac with an IC50 value of 4.6 nM in PC-3 cells,P300/CBP-IN-5 inhibits p300 LnCap-FGC cellls proliferation with an IC50 of 14.8 nM.?[1].
In vivo	Administration of P300/CBP-IN-5 (7.5 mg/kg/day) is initiated at the time of size match.?P300/CBP-IN-5 induces significant tumor growth inhibition in multiple xenograft tumor models (the tumor growth inhibition of 62% in SuDHL-8 xenograft tumor model;?48% in 22RV1 xenograft tumor model)[1].
Synonyms	P300/CBP-IN-5

Chemical Properties

Molecular Weight	618.55
Formula	C₂₉H₂₇F₅N₆O₄
Cas No.	1889284-33-6
Smiles	O=C1[C@]2(C=3C([C@H](F)C2)=CC(=CC3)C4=CN(CC(NC)=O)N=C4)NC(=O)N1CC(N(CC5=CC=C(F)C=C5)[C@H](C(F)(F)F)C)=O
Relative Density.	1.49 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc