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Anti-CD40 Monoclonal Antibody (1R963)

(Synonyms: TNFRSF5, p50, CDW40, Bp50) Copy Product Info
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Synonyms: TNFRSF5, p50, CDW40, Bp50

Catalog No. TMAT-0414 Copy Product Info
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Anti-CD40 Monoclonal Antibody (1R963) is a Mouse antibody targeting CD40. Anti-CD40 Monoclonal Antibody (1R963) can be used in WB,IHC,FCM.

Anti-CD40 Monoclonal Antibody
(1R963)

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Product Introduction

Bioactivity
Description
Anti-CD40 Monoclonal Antibody (1R963) is a Mouse antibody targeting CD40. Anti-CD40 Monoclonal Antibody (1R963) can be used in WB,IHC,FCM.
SynonymsTNFRSF5, p50, CDW40, Bp50
Ig Type
IgG1
Clone
1R963
Reactivity
Human
Application
Recommended Dose
WB: 1/500-1/2000; IHC: 1/200-1/1000; FCM: 1/200-1/400
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionHybridoma Monoclonal Antibody
PurificationPurified by protein A or protein G
AppearanceLiquid
FormulationPBS with 0.05% sodium azide
Concentration1 mg/ml
Research BackgroundThis gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014]
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Purified recombinant fragment of human CD40 (AA: extra(21-193)) expressed in E. Coli.
Antigen Species
Human
Gene Name
CD40
Gene ID
Protein Name
Tumor necrosis factor receptor superfamily member 5
Uniprot ID
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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