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Synonyms: TNFRSF5, p50, CDW40, Bp50
Anti-CD40 Monoclonal Antibody
(1R963)

| Description | Anti-CD40 Monoclonal Antibody (1R963) is a Mouse antibody targeting CD40. Anti-CD40 Monoclonal Antibody (1R963) can be used in WB,IHC,FCM. |
| Synonyms | TNFRSF5, p50, CDW40, Bp50 |
| Ig Type | IgG1 |
| Clone | 1R963 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1/500-1/2000; IHC: 1/200-1/1000; FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide |
| Concentration | 1 mg/ml |
| Research Background | This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014] |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human CD40 (AA: extra(21-193)) expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | CD40 |
| Gene ID | |
| Protein Name | Tumor necrosis factor receptor superfamily member 5 |
| Uniprot ID |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
| Size | Quantity | Unit Price | Amount | Operation |
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