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L-(-)-threo-3-Hydroxyaspartic acid

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Catalog No. T22916Cas No. 7298-99-9

L-(-)-threo-3-Hydroxyaspartic acid is an EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor.

L-(-)-threo-3-Hydroxyaspartic acid

L-(-)-threo-3-Hydroxyaspartic acid

Copy Product Info
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Catalog No. T22916Cas No. 7298-99-9
L-(-)-threo-3-Hydroxyaspartic acid is an EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mg$99035 days35 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Product Introduction

Bioactivity
Description
L-(-)-threo-3-Hydroxyaspartic acid is an EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor.
Chemical Properties
Molecular Weight149.1
FormulaC4H7NO5
Cas No.7298-99-9
Smiles[C@H]([C@@H](C(O)=O)O)(C(O)=O)N
Relative Density.1.738 g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
1eq. NaOH: 100 mM, Sonication is recommended.
Solution Preparation Table
1eq. NaOH
1mg5mg10mg50mg
1 mM6.7069 mL33.5345 mL67.0691 mL335.3454 mL
5 mM1.3414 mL6.7069 mL13.4138 mL67.0691 mL
10 mM0.6707 mL3.3535 mL6.7069 mL33.5345 mL
20 mM0.3353 mL1.6767 mL3.3535 mL16.7673 mL
50 mM0.1341 mL0.6707 mL1.3414 mL6.7069 mL
100 mM0.0671 mL0.3353 mL0.6707 mL3.3535 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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