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GSK467

Name: GSK467
Brand: TargetMol
SKU: T5484
Price: 63 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5484Cas No. 1628332-52-4

GSK467 is a potent and selective inhibitor of KDM5 (JARID1)(Ki : 10 nM).

GSK467

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Purity: 99.85%

Catalog No. T5484Cas No. 1628332-52-4

GSK467 is a potent and selective inhibitor of KDM5 (JARID1)(Ki : 10 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$63	In Stock	In Stock
5 mg	$152	In Stock	In Stock
10 mg	$229	In Stock	In Stock
25 mg	$426	In Stock	In Stock
50 mg	$662	-	In Stock
100 mg	$892	-	In Stock
1 mL x 10 mM (in DMSO)	$197	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.85%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

GSK467 AI Summary

GSK467 shows bioactivity as an inhibitor of various histone demethylase enzymes, specifically KDM4C, KDM4A, KDM4D, KDM4E, and KDM5C, with IC50 values ranging from 63.1 nM to 501.19 nM. It notably inhibits KDM5B with an IC50 value of 26.0 nM as determined by an alphascreen assay. The compound has a lipophilicity of LogD = 1.8 at pH 7.4. Additionally, it demonstrates antiviral activity by exhibiting 10.17% inhibition of SARS-CoV-2 3CL-Pro protease at a concentration of 20 µM, although its inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells is minimal, showing -0.05% in a high content imaging assay. However, it showed no significant inhibition against KDM6B and EGLN3..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	GSK467 is a potent and selective inhibitor of KDM5 (JARID1)(Ki : 10 nM).
Targets&IC50	KDM5 (JARID1):10 nM(Ki), KDM5:26 nM

Chemical Properties

Molecular Weight	319.32
Formula	C₁₇H₁₃N₅O₂
Cas No.	1628332-52-4
Smiles	O=c1[nH]c(Oc2cnn(Cc3ccccc3)c2)nc2cnccc12
Relative Density.	1.41 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20.83 mg/mL (65.23 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1317 mL	15.6583 mL	31.3165 mL	156.5827 mL
5 mM	0.6263 mL	3.1317 mL	6.2633 mL	31.3165 mL
10 mM	0.3132 mL	1.5658 mL	3.1317 mL	15.6583 mL
20 mM	0.1566 mL	0.7829 mL	1.5658 mL	7.8291 mL
50 mM	0.0626 mL	0.3132 mL	0.6263 mL	3.1317 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc