Lopinavir Metabolite M-1

Name: Lopinavir Metabolite M-1
Brand: TargetMol
SKU: T39345
Rating: 4.5 (1 reviews)

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Catalog No. T39345Cas No. 192725-39-6

Lopinavir Metabolite M-1, an active metabolite of Lopinavir, effectively inhibits the HIV protease enzyme with a Ki value of 0.7 pM, demonstrating notable antiviral properties in [in vitro] studies.

Lopinavir Metabolite M-1

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Catalog No. T39345Cas No. 192725-39-6

Lopinavir Metabolite M-1, an active metabolite of Lopinavir, effectively inhibits the HIV protease enzyme with a Ki value of 0.7 pM, demonstrating notable antiviral properties in [in vitro] studies.

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Product Introduction

Bioactivity

Description	Lopinavir Metabolite M-1, an active metabolite of Lopinavir, effectively inhibits the HIV protease enzyme with a Ki value of 0.7 pM, demonstrating notable antiviral properties in [in vitro] studies.
Targets&IC50	HIV protease:0.7 pM (IC50)
In vitro	Lopinavir Metabolite M-1 exhibits antiviral properties within MT-4 cells, achieving an EC50 (effective concentration 50) value of 1.413 μM[1].

Chemical Properties

Molecular Weight	642.78
Formula	C₃₇H₄₆N₄O₆
Cas No.	192725-39-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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