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Lisinopril

Name: Lisinopril
Brand: TargetMol
SKU: T21418
Price: 49 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21418Cas No. 76547-98-3

Alias Zestril, Prinivil, Lisipril, Linopril

Lisinopril (Prinivil), the angiotensin-converting enzyme (ACE) inhibitor, is used primarily in the treatment of high heart failure, blood pressure, and heart attacks. It is also used for preventing eye and kidney complications in people with diabetes.

Lisinopril

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Purity: 99.34%

Catalog No. T21418Alias Zestril, Prinivil, Lisipril, LinoprilCas No. 76547-98-3

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
200 mg	$49	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.34%

Appearance:Solid

Color:White

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COA HNMR HPLC

Product Introduction

Lisinopril AI Summary

Lisinopril exhibits potent inhibitory activity against the angiotensin-converting enzyme (ACE) with varying IC50 values measured in different assays, prominently including 1.2 nM and 0.1 nM in human serum assays. Its effectiveness in inhibiting ACE suggests potential uses in regulating blood pressure and cardiovascular function. Additionally, Lisinopril displays selectivity towards the ACE C domain over the N domain, with respective Ki values of 51.0 nM and 131.5 nM. Beyond ACE inhibition, this compound has demonstrated antiviral activity against SARS-CoV-2, although with moderate efficacy, and shows specific binding affinities to metal ions such as zinc and cupric. It has been assessed for various pharmacokinetic properties, including a half-life of 42 hours, a volume of distribution at 0.89 L.kg-1, and moderate total clearance and renal clearance each at 1.2 mL.min-1.kg-1. The compound exhibits low oral bioavailability (25.0%) and significant gut-wall elimination escape (Fg = 0.89). Additionally, it is involved in drug-related liver injury with a DILI severity class of 3.0, as evidenced by elevated liver enzyme levels. Lastly, Lisinopril shows inhibitory effects on rabbit and human liver transporters and modest cytotoxicity against human cell lines..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Lisinopril (Prinivil), the angiotensin-converting enzyme (ACE) inhibitor, is used primarily in the treatment of high heart failure, blood pressure, and heart attacks. It is also used for preventing eye and kidney complications in people with diabetes.
Synonyms	Zestril, Prinivil, Lisipril, Linopril

Chemical Properties

Molecular Weight	405.49
Formula	C₂₁H₃₁N₃O₅
Cas No.	76547-98-3
Smiles	C([C@@H](N[C@@H](CCC1=CC=CC=C1)C(O)=O)CCCCN)(=O)N2[C@H](C(O)=O)CCC2
Relative Density.	1.251 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: < 1 mg/mL (insoluble or slightly soluble)

H2O: 11.1 mg/mL (27.37 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.4662 mL	12.3308 mL	24.6615 mL	123.3076 mL
5 mM	0.4932 mL	2.4662 mL	4.9323 mL	24.6615 mL
10 mM	0.2466 mL	1.2331 mL	2.4662 mL	12.3308 mL
20 mM	0.1233 mL	0.6165 mL	1.2331 mL	6.1654 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc