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JLK6

Name: JLK6
Brand: TargetMol
SKU: T21890
Price: 80 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T21890Cas No. 62252-26-0

JLK6 was a gamma-secretase inhibitor that does not interfere with Notch signalling

JLK6

🥰Excellent

Purity: 96.50%

Catalog No. T21890Cas No. 62252-26-0

JLK6 was a gamma-secretase inhibitor that does not interfere with Notch signalling

Pack Size	Price	Availability
1 mg	$80	In Stock
5 mg	$163	In Stock
10 mg	$235	In Stock
25 mg	$393	In Stock
50 mg	$559	In Stock
100 mg	$762	In Stock
200 mg	$987	In Stock
1 mL x 10 mM (in DMSO)	$172	In Stock

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Questions

Batch Information

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Purity:96.50%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	JLK6 was a gamma-secretase inhibitor that does not interfere with Notch signalling
Targets&IC50	γ-secretase:10 μM-1 mM
In vitro	JLK6 markedly reduced Aβ secreted from HEK293 cells. Immunological characterization indicated that one fragment was labelled with a specific antibody against the Asp1 residue of Aβ[1].

Chemical Properties

Molecular Weight	225.63
Formula	C₁₀H₈ClNO₃
Cas No.	62252-26-0
Smiles	ClC=1C=2C(C(=O)OC1OC)=CC(N)=CC2
Relative Density.	1.46 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 22 mg/mL (97.5 mM), Sonication is recommended.

Ethanol: 5 mg/mL (22.16 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4320 mL	22.1602 mL	44.3203 mL	221.6017 mL
5 mM	0.8864 mL	4.4320 mL	8.8641 mL	44.3203 mL
10 mM	0.4432 mL	2.2160 mL	4.4320 mL	22.1602 mL
20 mM	0.2216 mL	1.1080 mL	2.2160 mL	11.0801 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0886 mL	0.4432 mL	0.8864 mL	4.4320 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc