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DNMDP

🥰Excellent
Catalog No. T15147Cas No. 328104-79-6

DNMDP is a potent and selective PDE3A inhibitor with anticancer activity. It binds to PDE3A, promoting its interaction with Schlafen 12 (SLFN12).

DNMDP
Other Forms of DNMDP:
(R)-DNMDPT138561630760-60-9
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DNMDP

🥰Excellent
Catalog No. T15147Cas No. 328104-79-6
DNMDP is a potent and selective PDE3A inhibitor with anticancer activity. It binds to PDE3A, promoting its interaction with Schlafen 12 (SLFN12).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$52-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
DNMDP is a potent and selective PDE3A inhibitor with anticancer activity. It binds to PDE3A, promoting its interaction with Schlafen 12 (SLFN12).
In vitro
Methods: DNMDP (2 nM-66.4 μM, 72 hours) was used to treat 766 genomically characterized cancer cell lines, and the cytotoxicity of DNMDP was evaluated through phenotypic screening.
Results: DNMDP exhibited significant selective toxicity toward specific cancer cell lines, with 22 cell lines showing high sensitivity to the drug (Z-score < -4), including multiple melanoma cell lines.[1]
Chemical Properties
Molecular Weight304.34
FormulaC15H20N4O3
Cas No.328104-79-6
SmilesO=C1NN=C(C(C1)C)C2=CC([N+]([O-])=O)=C(N(CC)CC)C=C2
Relative Density.1.28 g/cm3 (Predicted)
ColorOrange
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 40 mg/mL (131.43 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Saline: 2 mg/mL (6.57 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.2858 mL16.4290 mL32.8580 mL164.2899 mL
5 mM0.6572 mL3.2858 mL6.5716 mL32.8580 mL
10 mM0.3286 mL1.6429 mL3.2858 mL16.4290 mL
20 mM0.1643 mL0.8214 mL1.6429 mL8.2145 mL
50 mM0.0657 mL0.3286 mL0.6572 mL3.2858 mL
100 mM0.0329 mL0.1643 mL0.3286 mL1.6429 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

DNMDP
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