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Anti-Cadherin 17/CDH17 Antibody (7A680)
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Catalog No. TMAY-01849
Alias cadherin 17, LI cadherin (liver-intestine)
Anti-Cadherin 17/CDH17 Antibody (7A680) is a Rabbit antibody targeting Cadherin 17/CDH17. Anti-Cadherin 17/CDH17 Antibody (7A680) can be used in IHC-P.
Anti-Cadherin 17/CDH17 Antibody (7A680)
Anti-Cadherin 17/CDH17 Antibody (7A680)
😃Good
Catalog No. TMAY-01849Alias cadherin 17, LI cadherin (liver-intestine)
Anti-Cadherin 17/CDH17 Antibody (7A680) is a Rabbit antibody targeting Cadherin 17/CDH17. Anti-Cadherin 17/CDH17 Antibody (7A680) can be used in IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $269 | 7-10 days |
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| Description | Anti-Cadherin 17/CDH17 Antibody (7A680) is a Rabbit antibody targeting Cadherin 17/CDH17. Anti-Cadherin 17/CDH17 Antibody (7A680) can be used in IHC-P. |
| Alias | cadherin 17, LI cadherin (liver-intestine) |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 7A680 |
| Reactivity | Human |
| Verified Activity | 1. Immunochemical staining of human CDH17 in human rectal carcinoma with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). Positive staining was localized to intestinal gland. 2. Immunochemical staining of human CDH17 in human colon with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). Positive staining was localized to colonic gland. 3. Immunochemical staining of human CDH17 in human appendix with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). Positive staining was localized to intestinal gland. |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:100-1:500 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human Cadherin-17 / LI-cadherin / CDH17 (rh Cadherin-17 / LI-cadherin / CDH17; TMPY-01912; Q12864-1; Met1-Met787). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Cadherin-17 or LI-cadherin is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Cadherin-17/LI-cadherin is a cadherin-like protein consisting of an extracellular region, 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing of the encoding gene results in multiple transcript variants. Cadherin-17/LI-cadherin preferentially interact with themselves in a homophilic manner in connecting cells. Cadherin-17 may thus contribute to the sorting of heterogeneous cell types and have a role in the morphological organization of liver and intestine. It's also involved in intestinal peptide transport. Experiments have reported the association between Cadherin-17/LI-cadherin and gastric cancer. Cadherin-17/LI-cadherin expression was detected in 63/94 of gastric adenocarcinomas in addition to intestinal metaplasia. The expression of Cadherin-17 tended to be associated with intestinal type carcinoma, and carcinomas with Cadherin-17 expression was significantly more frequent in advanced stage cases than in early stage. Cadherin-17 is also a useful immunohistochemical marker for diagnosis of adenocarcinomas of the digestive system. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human Cadherin-17 / LI-cadherin / CDH17 protein (TMPY-01912) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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