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Anti-Granzyme B Antibody (6G558)
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Catalog No. TMAC-01707
Anti-Granzyme B Antibody (6G558) is a Mouse antibody targeting Granzyme B. Anti-Granzyme B Antibody (6G558) can be used in IF,IHC-P,IP,WB.
Anti-Granzyme B Antibody (6G558)
Anti-Granzyme B Antibody (6G558)
😃Good
Catalog No. TMAC-01707
Anti-Granzyme B Antibody (6G558) is a Mouse antibody targeting Granzyme B. Anti-Granzyme B Antibody (6G558) can be used in IF,IHC-P,IP,WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $296 | 7-10 days | 7-10 days | |
| 100 μL | $428 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Granzyme B Antibody (6G558) is a Mouse antibody targeting Granzyme B. Anti-Granzyme B Antibody (6G558) can be used in IF,IHC-P,IP,WB. |
| Clone | 6G558 |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | 1. Western blot analysis of granzyme B expression in non-transfected (A) and human granzyme B transfected (B) 293T whole cell lysates.
2. Immunoperoxidase staining of formalin fixed, paraffin-embedded human spleen tissue showing cytoplasmic staining of cells in red pulp.   |
| Application | |
| Recommended Dose | WB: 1:100-1000; IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate); IF: 1:50-1:200; IHC-P: 1:50-500 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | Granzyme A and granzyme B are serine proteases that mediate apoptotic signaling in cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. Both granzyme A and granzyme B are synthesized as inactive proenzymes, and they are stored within cytolytic granules and released by effector cells during degranulation. In activated CTLs, granzyme A and granzyme B are processed and activated by cathepsin C, and they then function to induce apoptosis by two distinct pathways. Granzyme B proteolytically cleaves and activates members of the caspase family of cysteine proteases, including caspase-3, caspase-6, caspase-7 and caspase-9. When cleaved, these caspases assemble into active holoenzymes that then mediate apoptosis through a defined proteolytic cascade involving nuclear lamins and PARP (poly ADP ribose polymerase). Granzyme A mediates the activation of apoptosis by inducing single-strand DNA breaks, membrane perturbation and nuclear condensations in an alternative pathway that is independent from caspase activation or the caspase proteolytic cascade. |
| Conjucates | Unconjugated |
| Immunogen | Amino acids 1-247 representing full length granzyme B of human origin |
| Antigen Species | human |
| Uniprot ID |
| Molecular Weight | Theoretical: 32 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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