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Anti-Granzyme B Antibody (6G558)

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Catalog No. TMAC-01707

Anti-Granzyme B Antibody (6G558) is a Mouse antibody targeting Granzyme B. Anti-Granzyme B Antibody (6G558) can be used in WB,IP,IF,IHC-P.

Anti-Granzyme B Antibody (6G558)

Anti-Granzyme B Antibody (6G558)

😃Good
Catalog No. TMAC-01707
Anti-Granzyme B Antibody (6G558) is a Mouse antibody targeting Granzyme B. Anti-Granzyme B Antibody (6G558) can be used in WB,IP,IF,IHC-P.
Pack SizePriceAvailabilityQuantity
50 μL$2967-10 days
100 μL$4287-10 days
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Product Introduction

Bioactivity
Description
Anti-Granzyme B Antibody (6G558) is a Mouse antibody targeting Granzyme B. Anti-Granzyme B Antibody (6G558) can be used in WB,IP,IF,IHC-P.
Reactivity
Human,Mouse,Rat
Application
Recommended Dose
WB: 1:100-1000; IHC-P: 1:50-500; IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionHybridoma Monoclonal Antibody
PurificationProA affinity purified
AppearanceLiquid
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Research BackgroundGranzyme A and granzyme B are serine proteases that mediate apoptotic signaling in cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. Both granzyme A and granzyme B are synthesized as inactive proenzymes, and they are stored within cytolytic granules and released by effector cells during degranulation. In activated CTLs, granzyme A and granzyme B are processed and activated by cathepsin C, and they then function to induce apoptosis by two distinct pathways. Granzyme B proteolytically cleaves and activates members of the caspase family of cysteine proteases, including caspase-3, caspase-6, caspase-7 and caspase-9. When cleaved, these caspases assemble into active holoenzymes that then mediate apoptosis through a defined proteolytic cascade involving nuclear lamins and PARP (poly ADP ribose polymerase). Granzyme A mediates the activation of apoptosis by inducing single-strand DNA breaks, membrane perturbation and nuclear condensations in an alternative pathway that is independent from caspase activation or the caspase proteolytic cascade.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Amino acids 1-247 representing full length granzyme B of human origin
Antigen Species
human
Uniprot ID
Chemical Properties
Molecular WeightTheoretical: 32 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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