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[D-Phe12,Leu14]-Bombesin

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Catalog No. TP1916Cas No. 108437-88-3

Bombesin receptor antagonist that inhibits bombesin binding to rat brain with an IC50 value of 2 μM. Inhibits amylase release in vitro (IC50 = 4 μM) and attenuates bombesin-mediated suppression of food intake in vivo.

[D-Phe12,Leu14]-Bombesin
Other Forms of [D-Phe12,Leu14]-Bombesin:
[D-Phe12,Leu14]-Bombesin acetateTP1916L1
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[D-Phe12,Leu14]-Bombesin

😃Good
Catalog No. TP1916Cas No. 108437-88-3
Bombesin receptor antagonist that inhibits bombesin binding to rat brain with an IC50 value of 2 μM. Inhibits amylase release in vitro (IC50 = 4 μM) and attenuates bombesin-mediated suppression of food intake in vivo.
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Product Introduction

Bioactivity
Description
Bombesin receptor antagonist that inhibits bombesin binding to rat brain with an IC50 value of 2 μM. Inhibits amylase release in vitro (IC50 = 4 μM) and attenuates bombesin-mediated suppression of food intake in vivo.
Chemical Properties
Molecular Weight1724.9
FormulaC77H113F3N22O20
Cas No.108437-88-3
Relative Density.no data available
Sequence{Glp}-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-{d-Phe}-Leu-Leu-NH2
Sequence Short{Glp}-QRLGNQWAVG-{d-Phe}-LL-NH2
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 10 mg/mL (5.8 mM), Sonication is recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM0.5797 mL2.8987 mL5.7974 mL28.9872 mL
5 mM0.1159 mL0.5797 mL1.1595 mL5.7974 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

[D Phe12,Leu14] Bombesin[D-Phe12,Leu14]-Bombesin[D-Phe-12,Leu14]-Bombesin[DPhe12,Leu14]Bombesin
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