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Gallopamil hydrochloride

Name: Gallopamil hydrochloride
Brand: TargetMol
SKU: T11353L
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11353LCas No. 16662-46-7

Alias Methoxyverapamil hydrochloride

Gallopamil hydrochloride (Methoxyverapamil hydrochloride) is an antagonist of phenylalkylamine calcium. Gallopamil hydrochloride can be used in antiarrhythmic and vasodilator studies.

Gallopamil hydrochloride

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Purity: 99.86%

Catalog No. T11353LAlias Methoxyverapamil hydrochlorideCas No. 16662-46-7

Gallopamil hydrochloride (Methoxyverapamil hydrochloride) is an antagonist of phenylalkylamine calcium. Gallopamil hydrochloride can be used in antiarrhythmic and vasodilator studies.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$32	In Stock	In Stock
5 mg	$67	In Stock	In Stock
10 mg	$92	In Stock	In Stock
25 mg	$143	In Stock	In Stock
50 mg	$193	In Stock	In Stock
100 mg	$297	-	In Stock
500 mg	$728	-	In Stock
1 mL x 10 mM (in DMSO)	$83	In Stock	In Stock

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Expected start date of shipmentUSA Warehouse [1-2 days] Global Warehouse [5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.86%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Gallopamil hydrochloride (Methoxyverapamil hydrochloride) is an antagonist of phenylalkylamine calcium. Gallopamil hydrochloride can be used in antiarrhythmic and vasodilator studies.
In vitro	Gallopamil hydrochloride inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 μM[1].
In vivo	In male Wistar rats, Gallopamil hydrochloride (0.2 mg/kg; i.v. for 5 min) markedly reduces ventricular tachycardia and totally prevents fibrillation. Gallopamil hydrochloride significantly reduces systolic and diastolic blood pressure measured 5 min after injection without markedly influencing heart rate[2].
Synonyms	Methoxyverapamil hydrochloride

Chemical Properties

Molecular Weight	521.09
Formula	C₂₈H₄₁ClN₂O₅
Cas No.	16662-46-7
Smiles	CC(C)C(CCCN(C)CCc(cc1)cc(OC)c1OC)(c(cc1OC)cc(OC)c1OC)C#N.Cl
Relative Density.	1.068g/cm3
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (115.14 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.84 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9191 mL	9.5953 mL	19.1905 mL	95.9527 mL
5 mM	0.3838 mL	1.9191 mL	3.8381 mL	19.1905 mL
10 mM	0.1919 mL	0.9595 mL	1.9191 mL	9.5953 mL
20 mM	0.0960 mL	0.4798 mL	0.9595 mL	4.7976 mL
50 mM	0.0384 mL	0.1919 mL	0.3838 mL	1.9191 mL
100 mM	0.0192 mL	0.0960 mL	0.1919 mL	0.9595 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc