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Biotin-COG1410 TFA
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Catalog No. TP3990
Biotin-COG1410 TFA is a biotinylated form of COG1410. COG1410 is a derivative peptide of apolipoprotein E and acts as an inhibitor of apoptosis. It exhibits neuroprotective and anti-inflammatory effects in a mouse traumatic brain injury (TBI) model. COG1410 is applicable for research in neurological disorders.
Biotin-COG1410 TFA
Biotin-COG1410 TFA
😃Good
Catalog No. TP3990
Biotin-COG1410 TFA is a biotinylated form of COG1410. COG1410 is a derivative peptide of apolipoprotein E and acts as an inhibitor of apoptosis. It exhibits neuroprotective and anti-inflammatory effects in a mouse traumatic brain injury (TBI) model. COG1410 is applicable for research in neurological disorders.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Biotin-COG1410 TFA is a biotinylated form of COG1410. COG1410 is a derivative peptide of apolipoprotein E and acts as an inhibitor of apoptosis. It exhibits neuroprotective and anti-inflammatory effects in a mouse traumatic brain injury (TBI) model. COG1410 is applicable for research in neurological disorders. |
| In vitro | Cog1410 (1-25 μm; 48 h) reduces the production and release of NO and TNFα in BV2 microglial cells. |
| In vivo | COG1410, administered as a single intravenous injection at doses of 0.3-0.6 mg/kg, significantly enhances short-term vestibular motor function and long-term spatial learning and memory in mice. At a dose of 0.8 mg/kg, COG1410 improves vestibular motor function in rats, reduces post-stroke motor asymmetry, and decreases the infarct volume in the ipsilateral hemisphere. |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyThe above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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