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AIM-100

Name: AIM-100
Brand: TargetMol
SKU: T5092
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T5092Cas No. 873305-35-2

Alias AIM100

AIM-100 is a Ack1 inhibitor (IC50: 24 nM).

AIM-100

🥰Excellent

Purity: 98.91%

Catalog No. T5092Alias AIM100Cas No. 873305-35-2

AIM-100 is a Ack1 inhibitor (IC50: 24 nM).

Pack Size	Price	Availability
2 mg	$42	In Stock
5 mg	$68	In Stock
10 mg	$105	In Stock
25 mg	$218	In Stock
50 mg	$378	In Stock
100 mg	$597	In Stock
1 mL x 10 mM (in DMSO)	$98	In Stock

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Batch Information

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Purity:98.91%

Resource Download

COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	AIM-100 is a Ack1 inhibitor (IC50: 24 nM).
Targets&IC50	Ack1:24 nM
In vitro	AIM-100 not only inhibited Ack1 activation but also suppressed AKT tyrosine phosphorylation, leading to cell cycle arrest in the G1 phase [1]. It also was able to suppress AR Tyr(267) phosphorylation and its recruitment to the ATM enhancer. Notably, AIM-100 suppressed Ack1 mediated ATM expression and mitigated the growth of radioresistant CRPC tumors [2]. AIM-100, not only inhibited Ack1 activation but also able to suppress pTyr267-AR phosphorylation, binding of AR to PSA, NKX3.1, and TMPRSS2 promoters, and inhibit AR transcription activity [3].
Synonyms	AIM100

Chemical Properties

Molecular Weight	371.43
Formula	C₂₃H₂₁N₃O₂
Cas No.	873305-35-2
Smiles	C(Nc1ncnc2oc(c(-c3ccccc3)c12)-c1ccccc1)C1CCCO1
Relative Density.	1.243 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (161.54 mM), Sonication is recommended.

Ethanol: 30 mg/mL (80.77 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6923 mL	13.4615 mL	26.9230 mL	134.6149 mL
5 mM	0.5385 mL	2.6923 mL	5.3846 mL	26.9230 mL
10 mM	0.2692 mL	1.3461 mL	2.6923 mL	13.4615 mL
20 mM	0.1346 mL	0.6731 mL	1.3461 mL	6.7307 mL
50 mM	0.0538 mL	0.2692 mL	0.5385 mL	2.6923 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0269 mL	0.1346 mL	0.2692 mL	1.3461 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc