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DG051

Name: DG051
Brand: TargetMol
SKU: TQ0047
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TQ0047Cas No. 929915-58-2

DG051 is a potent leukotriene A4 hydrolase (LTA4H) inhibitor with an IC50 of 47 nM.

DG051

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Purity: 98.26%

Catalog No. TQ0047Cas No. 929915-58-2

DG051 is a potent leukotriene A4 hydrolase (LTA4H) inhibitor with an IC50 of 47 nM.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$31	In Stock	In Stock
5 mg	$68	In Stock	In Stock
10 mg	$118	In Stock	In Stock
25 mg	$251	In Stock	In Stock
50 mg	$401	In Stock	In Stock
100 mg	$642	In Stock	In Stock
200 mg	$858	-	In Stock
1 mL x 10 mM (in DMSO)	$76	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.26%

Appearance:Viscous

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	DG051 is a potent leukotriene A4 hydrolase (LTA4H) inhibitor with an IC50 of 47 nM.
Targets&IC50	LTA4H:47 nM (IC50)
In vitro	DG051 is a potent LTA4H aminopeptidase inhibitor against L-alanine p-nitroanilide (IC50: 72 nM) and suppresses human whole blood (HWB) with an IC50 of 37 nM [1]. DG051 is currently in Phase II clinical development for preventing heart attacks as an LTA4H inhibitor [2].

Chemical Properties

Molecular Weight	426.33
Formula	C₂₁H₂₅Cl₂NO₄
Cas No.	929915-58-2
Smiles	Cl.OC(=O)CCCN1CCC[C@H]1COc1ccc(Oc2ccc(Cl)cc2)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 317 mg/mL (743.56 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3456 mL	11.7280 mL	23.4560 mL	117.2800 mL
5 mM	0.4691 mL	2.3456 mL	4.6912 mL	23.4560 mL
10 mM	0.2346 mL	1.1728 mL	2.3456 mL	11.7280 mL
20 mM	0.1173 mL	0.5864 mL	1.1728 mL	5.8640 mL
50 mM	0.0469 mL	0.2346 mL	0.4691 mL	2.3456 mL
100 mM	0.0235 mL	0.1173 mL	0.2346 mL	1.1728 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc