IFNGR1 Protein, Human, Recombinant (His)

Name: IFNGR1 Protein, Human, Recombinant (His)
Brand: TargetMol
SKU: TMPY-01151
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: interferon γ receptor 1, interferon gamma receptor 1, IMD27B, IMD27A, IFNGR, CD119) Copy Product Info

Synonyms: interferon γ receptor 1, interferon gamma receptor 1, IMD27B, IMD27A, IFNGR, CD119

Catalog No. TMPY-01151 Copy Product Info

Purity: 97.5%

IFNGR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.3 kDa and the accession number is A0A0S2Z3Y2.

Pack Size	Price	USA Stock	Global Stock
5 µg	$35	-	In Stock
10 µg	$52	-	In Stock
20 µg	$81	-	In Stock
50 µg	$153	-	In Stock
100 µg	$255	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:97.5%

Appearance:Lyophilized powder

Color:White

Resource Download

COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Measured by its ability to inhibit rhIFNγ mediated protection of WISH cells infected with vesicular stomatitis virus(VSV). The ED50 for this effect is typically 2-8 μg/mL.
Description	IFNGR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.3 kDa and the accession number is A0A0S2Z3Y2.
Species	Human
Expression System	HEK293 Cells
Tag	C-His
Accession Number	P15260
Construction	A DNA sequence encoding the extracellular domain (Met 1-Gly 245) of human IFN-γR1 pre-protein (NP_000407.1) was expressed, fused with a polyhistidine tag at the C-terminus. Predicted N terminal: Glu 18
Protein Purity	> 97 % as determined by SDS-PAGE
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot.
Synonyms	interferon γ receptor 1, interferon gamma receptor 1, IMD27B, IMD27A, IFNGR, CD119
Research Background	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alters the behavior of the cell. Some CD proteins do not take part in the cell signal process but have other functions such as cell adhesion. CD119 (cluster of differentiation 119), also known as IFNGR1 ( interferon-gamma receptor 1), is part of the heterodimeric gamma interferon receptor which consists of IFNGR1 (CD119) and IFNGR2. The IFNGR1 gene encodes the ligand-binding chain (alpha) of the interferon receptor while the IFNGR gene encodes the non-ligand binding partner. The ability of the interferon-γ was achieved through binding to the interferon receptor CD119. After binding, the products of activated T-lymphocytes interferon-γ exerts antiviral activity, growth inhibitory effect, and several immune- regulatory activities on a variety of cell types.

Chemical Properties

Molecular Weight

27.3 kDa (predicted); 40-35 kDa (reducing condition, due to glycosylation)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.