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Olcegepant hydrochloride

Name: Olcegepant hydrochloride
Brand: TargetMol
SKU: T12293
Rating: 4.5 (1 reviews)

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Catalog No. T12293Cas No. 586368-06-1

Alias BIBN4096BS hydrochloride, BIBN-4096 hydrochloride, BIBN4096 hydrochloride, BIBN 4096BS hydrochloride

Olcegepant hydrochloride (BIBN-4096 hydrochloride) is a selective calcitonin gene-related peptide 1 (CGRP1) receptor antagonist with an IC50=0.03 nM and Ki=14.4 pM.

Olcegepant hydrochloride

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Purity: 99.69%

Catalog No. T12293Alias BIBN4096BS hydrochloride, BIBN-4096 hydrochloride, BIBN4096 hydrochloride, BIBN 4096BS hydrochlorideCas No. 586368-06-1

Olcegepant hydrochloride (BIBN-4096 hydrochloride) is a selective calcitonin gene-related peptide 1 (CGRP1) receptor antagonist with an IC50=0.03 nM and Ki=14.4 pM.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$107	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.69%

Appearance:Solid

Color:Yellow

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COA

Product Introduction

Bioactivity

Description	Olcegepant hydrochloride (BIBN-4096 hydrochloride) is a selective calcitonin gene-related peptide 1 (CGRP1) receptor antagonist with an IC50=0.03 nM and Ki=14.4 pM.
Targets&IC50	CGRP:0.03 nM
In vitro	Olcegepant hydrochloride shows high binding affinity to human CGRP receptors (IC₅₀ = 0.03 nM) and pure antagonist behavior (pA₂ = 11.1) in SK-N-MC cells[1].
In vivo	In Wistar rats, Olcegepant hydrochloride (900 μg/kg, i.v.) reduced capsaicin-induced Fos expression in the spinal trigeminal nucleus by 57%, with no effect on trigeminal ganglion pERK, indicating a central site of CGRP receptor inhibition[4].
Synonyms	BIBN4096BS hydrochloride, BIBN-4096 hydrochloride, BIBN4096 hydrochloride, BIBN 4096BS hydrochloride

Chemical Properties

Molecular Weight	906.11
Formula	C₃₈H₄₈Br₂ClN₉O₅
Cas No.	586368-06-1
Smiles	O=C1N(CC=2C(N1)=CC=CC2)C3CCN(C(N[C@H](CC4=CC(Br)=C(O)C(Br)=C4)C(N[C@H](C(=O)N5CCN(CC5)C=6C=CN=CC6)CCCCN)=O)=O)CC3.Cl
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (88.29 mM), Sonication is recommended.

H2O: 50 mg/mL (55.18 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 5 mg/mL (5.52 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1036 mL	5.5181 mL	11.0362 mL	55.1809 mL
5 mM	0.2207 mL	1.1036 mL	2.2072 mL	11.0362 mL
10 mM	0.1104 mL	0.5518 mL	1.1036 mL	5.5181 mL
20 mM	0.0552 mL	0.2759 mL	0.5518 mL	2.7590 mL
50 mM	0.0221 mL	0.1104 mL	0.2207 mL	1.1036 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc