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DBCO-PEG5-NHS ester

Name: DBCO-PEG5-NHS ester
Brand: TargetMol
SKU: T15075
Price: 61 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15075Cas No. 2144395-59-3

DBCO-PEG5-NHS ester is a PROTAC linker belonging to the PEG and Alkyl/ether classes for the synthesis of a range of PROTAC molecules.

DBCO-PEG5-NHS ester

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Purity: 98.18%

Catalog No. T15075Cas No. 2144395-59-3

DBCO-PEG5-NHS ester is a PROTAC linker belonging to the PEG and Alkyl/ether classes for the synthesis of a range of PROTAC molecules.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$61	-	In Stock
5 mg	$147	In Stock	In Stock
10 mg	$228	In Stock	In Stock
25 mg	$428	In Stock	In Stock
50 mg	$655	-	In Stock
100 mg	$932	-	In Stock
200 mg	$1,270	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.18%

Appearance:Viscous

Color:Yellow

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	DBCO-PEG5-NHS ester is a PROTAC linker belonging to the PEG and Alkyl/ether classes for the synthesis of a range of PROTAC molecules.
In vitro	PROTACs consist of two different ligands that are linked by a linker, one of which is directed against the E3 ubiquitin ligase and the other against the target protein.PROTACs selectively degrade target proteins through the intracellular ubiquitin-proteasome system. ADCs consist of an antibody, a linker, and a cytotoxin, which binds to the antibody through the linker.

Chemical Properties

Molecular Weight	693.74
Formula	C₃₆H₄₃N₃O₁₁
Cas No.	2144395-59-3
Smiles	O=C(ON1C(=O)CCC1=O)CCOCCOCCOCCOCCOCCNC(=O)CCC(=O)N2C=3C=CC=CC3C#CC=4C=CC=CC4C2
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (115.32 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4415 mL	7.2073 mL	14.4146 mL	72.0731 mL
5 mM	0.2883 mL	1.4415 mL	2.8829 mL	14.4146 mL
10 mM	0.1441 mL	0.7207 mL	1.4415 mL	7.2073 mL
20 mM	0.0721 mL	0.3604 mL	0.7207 mL	3.6037 mL
50 mM	0.0288 mL	0.1441 mL	0.2883 mL	1.4415 mL
100 mM	0.0144 mL	0.0721 mL	0.1441 mL	0.7207 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc