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SR10221

Name: SR10221
Brand: TargetMol
SKU: T88393
Rating: 4.5 (1 reviews)

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Catalog No. T88393Cas No. 1415321-64-0

Alias SR-10221, SR 10221

SR10221 is a noncovalent inverse agonist of PPARγ that represses downstream PPARγ target gene expression, leading to growth inhibition in bladder cancer cell lines, SR10221 is extensively utilized to explore PPARγ-driven transcriptional programs, metabolic regulation, and the therapeutic potential of inverse agonism in oncology research.

SR10221

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Catalog No. T88393Alias SR-10221, SR 10221Cas No. 1415321-64-0

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 mg	Inquiry	10-14 weeks	10-14 weeks
50 mg	Inquiry	10-14 weeks	10-14 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

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Product Introduction

Bioactivity

Description	SR10221 is a noncovalent inverse agonist of PPARγ that represses downstream PPARγ target gene expression, leading to growth inhibition in bladder cancer cell lines, SR10221 is extensively utilized to explore PPARγ-driven transcriptional programs, metabolic regulation, and the therapeutic potential of inverse agonism in oncology research.
Synonyms	SR-10221, SR 10221

Chemical Properties

Molecular Weight	561.11
Formula	C₃₃H₃₇ClN₂O₄
Cas No.	1415321-64-0
Smiles	C(N1C=2C(=CC(C(N[C@@H](C)C3=CC=C(C(C)(C)C)C=C3)=O)=CC2)C(C)=C1C)C4=CC(O[C@H](C(O)=O)C)=C(Cl)C=C4

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 100 mg/mL (178.22 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7822 mL	8.9109 mL	17.8218 mL	89.1091 mL
5 mM	0.3564 mL	1.7822 mL	3.5644 mL	17.8218 mL
10 mM	0.1782 mL	0.8911 mL	1.7822 mL	8.9109 mL
20 mM	0.0891 mL	0.4455 mL	0.8911 mL	4.4555 mL
50 mM	0.0356 mL	0.1782 mL	0.3564 mL	1.7822 mL
100 mM	0.0178 mL	0.0891 mL	0.1782 mL	0.8911 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

SR10221

SR10221

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In Vivo Formulation Calculator (Clear solution)

Dose Conversion

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