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PluriSIn #2
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Catalog No. T36301Cas No. 56563-17-8
PluriSIn #2 acts as a selective transcriptional inhibitor of topoisomerase II α (TOP2A) and effectively eliminates undifferentiated human pluripotent stem cells (hPSCs)[1].
PluriSIn #2
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Purity: 99.79%
Catalog No. T36301Cas No. 56563-17-8
PluriSIn #2 acts as a selective transcriptional inhibitor of topoisomerase II α (TOP2A) and effectively eliminates undifferentiated human pluripotent stem cells (hPSCs)[1].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $84 | - | In Stock | |
| 5 mg | $198 | - | In Stock | |
| 10 mg | $372 | - | In Stock | |
| 25 mg | $689 | - | In Stock | |
| 50 mg | Preferential | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $226 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.79%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | PluriSIn #2 acts as a selective transcriptional inhibitor of topoisomerase II α (TOP2A) and effectively eliminates undifferentiated human pluripotent stem cells (hPSCs)[1]. |
| In vitro | PluriSIn #2 (20 μM; 12 hours) treatment reduces TOP2A expression at the protein level[1].A 24h exposure of PluriSIn #2 (20 μM) is sufficient to induce massive cell death in hPSCs, but doesn't affect the viability of various other cell types derived from them[1]. Western Blot Analysis[1]Cell Line: B153 and HUES9 human pluripotent stem cells (hPSCs) |
| Molecular Weight | 249.2 |
| Formula | C11H8FN3O3 |
| Cas No. | 56563-17-8 |
| Smiles | Fc1cn(C(=O)Nc2ccccc2)c(=O)[nH]c1=O |
| Storage | The compound is unstable in solution. Please use soon,keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 4 mg/mL (16.05 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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