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Anti-MEK3 Antibody (1C515)
😃Good
Catalog No. TMAB-08735
Anti-MEK3 Antibody (1C515) is a Rabbit antibody targeting MEK3. Anti-MEK3 Antibody (1C515) can be used in WB.
Anti-MEK3 Antibody (1C515)
Anti-MEK3 Antibody (1C515)
😃Good
Catalog No. TMAB-08735
Anti-MEK3 Antibody (1C515) is a Rabbit antibody targeting MEK3. Anti-MEK3 Antibody (1C515) can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $148 | 7-10 days | 7-10 days | |
| 50 μL | $263 | 7-10 days | 7-10 days | |
| 100 μL | $471 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-MEK3 Antibody (1C515) is a Rabbit antibody targeting MEK3. Anti-MEK3 Antibody (1C515) can be used in WB. |
| Ig Type | IgG |
| Clone | 1C515 |
| Reactivity | Human (predicted:Mouse,Rat) |
| Application | |
| Recommended Dose | WB: 1:500-1000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm; cytoskeleton. |
| Tissue Specificity | Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq]. |
| Immunogen | KLH conjugated synthetic peptide: human MEK3 |
| Antigen Species | Human |
| Gene Name | MAP2K3 |
| Gene ID | |
| Protein Name | Dual specificity mitogen-activated protein kinase kinase 3 |
| Uniprot ID | |
| Function | Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. |
| Molecular Weight | Theoretical: 39 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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