MC-Sq-Cit-PAB-Dolastatin10

Name: MC-Sq-Cit-PAB-Dolastatin10
Brand: TargetMol
SKU: T18315
Rating: 4.5 (1 reviews)

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Catalog No. T18315Cas No. 1941168-65-5

MC-Sq-Cit-PAB-Dolastatin10 is a potent antitumor drug-linker conjugate for Antibody-Drug Conjugates (ADC), incorporating Dolastatin10 (a tubulin polymerization inhibitor) connected via the MC-Sq-Cit-PAB ADC linker.

MC-Sq-Cit-PAB-Dolastatin10

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Catalog No. T18315Cas No. 1941168-65-5

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description

In vitro

ADC1-2 (anti-CD22 10F4v3 LC K149C MC-Sq-Cit-PAB-Dolastatin 10) demonstrates selective cytotoxicity against WSU-DLCL2 human diffuse large B-cell lymphoma tumors with an IC50 value of 0.385 nM. Similarly, ADC1-1 (anti-Napi2b 10H1 11.4B LC K149C MC-Sq-Cit-PAB-Dolastatin 10) exhibits specific cytotoxic effects on human ovarian cancer cell lines IGROV-1 and OVCAR-3x2.1, with IC50 values of 3.19 nM and 1.52 nM, respectively[1].

Chemical Properties

Molecular Weight	1338.72
Formula	C₇₀H₁₀₅N₁₂O₁₂S
Cas No.	1941168-65-5
Smiles	C(N[C@H](C(NC1=CC=C(C[N+]([C@H](C(N[C@H](C(N([C@H]([C@@H](CC(=O)N2[C@]([C@@H]([C@H](C(N[C@@H](CC3=CC=CC=C3)C4=NC=CS4)=O)C)OC)(CCC2)[H])OC)[C@H](CC)C)C)=O)C(C)C)=O)[C@@H](C)C)(C)C)C=C1)=O)CCCNC(N)=O)(=O)C5(C(NCCCCCN6C(=O)C=CC6=O)=O)CCC5
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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