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SB 204990

Name: SB 204990
Brand: TargetMol
SKU: T16861
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T16861Cas No. 154566-12-8

SB 204990 is a lactone prodrug of SB-201076, a potent and specific ATP citrate lyase inhibitor.

SB 204990

🥰Excellent

Purity: 99.6%

Catalog No. T16861Cas No. 154566-12-8

SB 204990 is a lactone prodrug of SB-201076, a potent and specific ATP citrate lyase inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$39	In Stock	In Stock
5 mg	$93	In Stock	In Stock
10 mg	$163	In Stock	In Stock
25 mg	$323	In Stock	In Stock
50 mg	$593	In Stock	In Stock
100 mg	$848	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$97	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.6%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	SB 204990 is a lactone prodrug of SB-201076, a potent and specific ATP citrate lyase inhibitor.
In vitro	METHODS: Primary hepatocytes were treated with SB-204990 (10 μM, 16 hours) under different experimental conditions to determine the effects occurring early after exposure to the Acly inhibitor SB-204990. RESULTS Phosphorylation of pThr 172 Ampk and pSer 79 Acc was reduced in primary hepatocytes treated with SB-204990 for 16 hours, while markers of Sirt1 or mTOR activity were absent. [1]
In vivo	METHODS: Mice were treated with SB-204990 (30 mg/kg body weight; oral gavage; treatment for 3 hours) to determine whether SB-204990 could induce effects in mitochondria in vivo. RESULTS Freshly isolated liver mitochondria from mice showed blocking and limiting effects on ADP-induced and FCCP-induced increases in OCR, respectively. [1]

Chemical Properties

Molecular Weight	389.27
Formula	C₁₈H₂₂Cl₂O₅
Cas No.	154566-12-8
Smiles	OC(=O)C[C@@]1(O)C[C@@H](CCCCCCc2ccc(Cl)cc2Cl)OC1=O
Relative Density.	1.332 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 242 mg/mL (621.68 mM), Sonication is recommended.

H2O: 10 mg/mL (25.69 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (12.84 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5689 mL	12.8446 mL	25.6891 mL	128.4456 mL
5 mM	0.5138 mL	2.5689 mL	5.1378 mL	25.6891 mL
10 mM	0.2569 mL	1.2845 mL	2.5689 mL	12.8446 mL
20 mM	0.1284 mL	0.6422 mL	1.2845 mL	6.4223 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0514 mL	0.2569 mL	0.5138 mL	2.5689 mL
100 mM	0.0257 mL	0.1284 mL	0.2569 mL	1.2845 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc