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Anti-RhoA Antibody (4W246)

😃Good
Catalog No. TMAY-02350
Alias RHOH12, RHO12, ras homolog family member A, ARHA, ARH12

Anti-RhoA Antibody (4W246) is a Rabbit antibody targeting RhoA. Anti-RhoA Antibody (4W246) can be used in FCM.

Anti-RhoA Antibody (4W246)

Anti-RhoA Antibody (4W246)

😃Good
Catalog No. TMAY-02350Alias RHOH12, RHO12, ras homolog family member A, ARHA, ARH12
Anti-RhoA Antibody (4W246) is a Rabbit antibody targeting RhoA. Anti-RhoA Antibody (4W246) can be used in FCM.
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100 μL$268 7-10 days
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Product Introduction

Bioactivity
Description
Anti-RhoA Antibody (4W246) is a Rabbit antibody targeting RhoA. Anti-RhoA Antibody (4W246) can be used in FCM.
AliasRHOH12, RHO12, ras homolog family member A, ARHA, ARH12
Ig Type
Monoclonal Rabbit IgG
Clone
4W246
Reactivity
Human
Verified Activity
Flow cytometric analysis of Human RHOA expression on HeLa cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), stained with purified anti-Human RHOA, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Application
FCM
Recommended Dose
FCM: 1:25-1:100
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionThis antibody was obtained from a rabbit immunized with purified, recombinant Human RhoA (rh RhoA; TMPY-01958; P61586-1; Met1-Leu193).
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundTransforming protein RhoA, also known as Rho cDNA clone 12, Ras homolog gene family member A, RHOA and ARH12, is a cell membrane and cytoplasm protein that belongs to the small GTPase superfamily and Rho family. The Rho family of small GTPases plays a key role in the dynamic regulation of the actin cytoskeleton that underlies various important cellular functions such as shape changes, migration, and polarity. RHOA / ARH12 is part of a larger family of related proteins known as the Ras superfamily; proteins involved in the regulation and timing of cell division. RHOA / ARH12 is a small GTPase protein known to regulate the actin cytoskeleton in the formation of stress fibers. It acts upon two known effector proteins: ROCK1 (Rho-associated, coiled-coil containing protein kinase 1) and DIAPH1 ( diaphanous homolog 1 (Drosophila) ). RHOA / ARH12 regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. RHOA / ARH12 serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. RHOA / ARH12 may be an activator of PLCE1. It is activated by ARHGEF2, which promotes the exchange of GDP for GTP.
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
FITC
Antibody Types Available
2
Antigen Details
Immunogen
Recombinant Human RhoA Protein (TMPY-01958)
Antigen Species
Human
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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