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Thiacetazone

Name: Thiacetazone
Brand: TargetMol
SKU: T7877
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7877Cas No. 104-06-3

Alias Thioacetazone, Neustab, Neotibil, Diazam

Thiacetazone (Diazam) is a thiosemicarbazone that thioacetazone treatment of pulmonary tuberculosis

Thiacetazone

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Purity: 99.07%

Catalog No. T7877Alias Thioacetazone, Neustab, Neotibil, DiazamCas No. 104-06-3

Thiacetazone (Diazam) is a thiosemicarbazone that thioacetazone treatment of pulmonary tuberculosis

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$34	In Stock	In Stock
500 mg	$53	-	In Stock
1 g	$77	-	In Stock
1 mL x 10 mM (in DMSO)	$53	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.07%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Thiacetazone AI Summary

Thiacetazone exhibits a range of biological activities, demonstrating significant antimicrobial and antiviral properties. It possesses potent antimycobacterial activity with minimum inhibitory concentrations (MIC) ranging from 0.1 to 2.5 µg/mL against various strains of Mycobacterium bovis BCG and Mycobacterium tuberculosis, showing potential as a treatment for mycobacterial infections. The compound also shows antimicrobial activity against non-replicating Mycobacterium tuberculosis H37Rv under both aerobic and anaerobic conditions, although its effectiveness varies with MIC values reaching up to 128,000 nM. Additionally, Thiacetazone exhibits antiviral activity against SARS-CoV-2, with IC50 values around 20,000 nM, suggesting it could be a candidate for further development as an antiviral agent. It also inhibits multiple biological targets including Cruzain, Bacillus subtilis Sfp phosphopantetheinyl transferase, and Giardia lamblia fructose-1,6-bisphosphate aldolase, with potencies ranging from 11.22 µM to 89.12 µM. Despite these promising activities, Thiacetazone has been identified to have significant cytotoxicity against human cell lines and various forms of hepatotoxicity, including liver toxicity and severe hepatitis. It also inhibits human bile salt export pump (BSEP) and multidrug resistance-associated proteins (MRP2, MRP3, and MRP4) with IC50 values greater than 133,000 nM. Finally, Thiacetazone shows inhibitory activity against mushroom tyrosinase with an IC50 value of 14,000 nM. However, it does not exhibit significant bioactivity against a variety of receptors and enzymes tested in different assays, as all results showed AC50 values above 30,000 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Thiacetazone (Diazam) is a thiosemicarbazone that thioacetazone treatment of pulmonary tuberculosis
Targets&IC50	Mycobacterium tuberculosis H37Rv:0.1 μg/mL (MIC)
Synonyms	Thioacetazone, Neustab, Neotibil, Diazam

Chemical Properties

Molecular Weight	236.29
Formula	C₁₀H₁₂N₄OS
Cas No.	104-06-3
Smiles	CC(=O)Nc1ccc(\C=N\NC(N)=S)cc1
Relative Density.	1.2752 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 22.5 mg/mL (95.22 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.46 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2321 mL	21.1604 mL	42.3209 mL	211.6044 mL
5 mM	0.8464 mL	4.2321 mL	8.4642 mL	42.3209 mL
10 mM	0.4232 mL	2.1160 mL	4.2321 mL	21.1604 mL
20 mM	0.2116 mL	1.0580 mL	2.1160 mL	10.5802 mL
50 mM	0.0846 mL	0.4232 mL	0.8464 mL	4.2321 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc