SMARCA2 Protein, Human, Recombinant (His)

Name: SMARCA2 Protein, Human, Recombinant (His)
Brand: TargetMol
SKU: TMPH-01905
Rating: 4.5 (1 reviews)

(Synonyms: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2, SNF2L2, SNF2-alpha, SNF2A, SMARCA2, Protein brahma homolog (hBRM), Probable global transcription activator SNF2L2, BRM, BRG1-associated factor 190B (BAF190B), BAF190B, ATP-dependent helicase SMARCA2) Copy Product Info

Synonyms: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2, SNF2L2, SNF2-alpha, SNF2A, SMARCA2, Protein brahma homolog (hBRM), Probable global transcription activator SNF2L2, BRM, BRG1-associated factor 190B (BAF190B), BAF190B, ATP-dependent helicase SMARCA2

Catalog No. TMPH-01905 Copy Product Info

SMARCA2 Protein, Human, Recombinant (His) is expressed in Yeast.

Pack Size	Price	USA Stock	Global Stock
5 µg	$86	20 days	20 days
10 µg	$138	20 days	20 days
20 µg	$231	20 days	20 days
50 µg	$348	20 days	20 days
100 µg	$480	20 days	20 days
200 µg	$743	20 days	20 days
500 µg	$1,330	20 days	20 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	SMARCA2 Protein, Human, Recombinant (His) is expressed in Yeast.
Species	Human
Expression System	P. pastoris (Yeast)
Tag	N-6xHis
Accession Number	P51531
Amino Acid	SYYTVAHAISERVEKQSALLINGTLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIVPLSTLSNWTYEFDKWAPSVVKISYKGTPAMRRSLVPQLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGERVDLNEEETILIIRRLHKVLRPFLLRRLKKEVESQLPEKVEYVIKCDMSALQKILYRHMQAKGILLTDGSEKDKKGKGGAKTLMNTIMQLRKICNHPYMFQHIEESFAEHLGYSNGVINGAELYRASGKFELLDRILPKLRATNHRVLLFCQMTSLMTIMEDYFAFRNFLYLRLDGTTKSEDRAALLKKFNEPGSQYFIFLLSTRAGGLGLNLQAADTVVIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAF
Construction	700-1216 aa
Protein Purity	> 90% as determined by SDS-PAGE.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Tris-based buffer, 50% glycerol
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonyms	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2, SNF2L2, SNF2-alpha, SNF2A, SMARCA2, Protein brahma homolog (hBRM), Probable global transcription activator SNF2L2, BRM, BRG1-associated factor 190B (BAF190B), BAF190B, ATP-dependent helicase SMARCA2
Research Background	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.

Chemical Properties

Molecular Weight

61.7 kDa (predicted)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.