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Demethylzeylasteral

🥰Excellent
Catalog No. T3418Cas No. 107316-88-1
Alias Demethylzeylasteral (T-96)

Demethylzeylasteral (T-96), isolated from Tripterygium wilfordii, has anti-inflammatory, immunosuppressive and anti-tumor activities. It inhibits the invasion of triple-negative breast cancer by blocking the TGF-β signaling pathway, and it can significantly reduce atherosclerosis.

Demethylzeylasteral

Demethylzeylasteral

🥰Excellent
Purity: 99.82%
Catalog No. T3418Alias Demethylzeylasteral (T-96)Cas No. 107316-88-1
Demethylzeylasteral (T-96), isolated from Tripterygium wilfordii, has anti-inflammatory, immunosuppressive and anti-tumor activities. It inhibits the invasion of triple-negative breast cancer by blocking the TGF-β signaling pathway, and it can significantly reduce atherosclerosis.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$45In StockIn Stock
10 mg$68In StockIn Stock
25 mg$117In StockIn Stock
50 mg$152In StockIn Stock
100 mg$197In StockIn Stock
1 mL x 10 mM (in DMSO)$50In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.82%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
Demethylzeylasteral (T-96), isolated from Tripterygium wilfordii, has anti-inflammatory, immunosuppressive and anti-tumor activities. It inhibits the invasion of triple-negative breast cancer by blocking the TGF-β signaling pathway, and it can significantly reduce atherosclerosis.
Targets&IC50
UGT1A6:0.6 μM(Ki), UGT2B7:17.3 μM(Ki)
SynonymsDemethylzeylasteral (T-96)
Chemical Properties
Molecular Weight480.59
FormulaC29H36O6
Cas No.107316-88-1
Smiles[H][C@@]12C[C@@](C)(CC[C@]1(C)CC[C@]1(C)C3=CC(=O)c4c(C=O)c(O)c(O)cc4[C@]3(C)CC[C@@]21C)C(O)=O
Relative Density.1.31 g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 87 mg/mL (181.03 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.87 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0808 mL10.4039 mL20.8078 mL104.0388 mL
5 mM0.4162 mL2.0808 mL4.1616 mL20.8078 mL
10 mM0.2081 mL1.0404 mL2.0808 mL10.4039 mL
20 mM0.1040 mL0.5202 mL1.0404 mL5.2019 mL
50 mM0.0416 mL0.2081 mL0.4162 mL2.0808 mL
100 mM0.0208 mL0.1040 mL0.2081 mL1.0404 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

UGT2B7UGT1A6T-96T96T 96InhibitorinhibitDemethylzeylasteralApoptosis
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