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TYA-018

Name: TYA-018
Brand: TargetMol
SKU: T73464
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T73464Cas No. 2653254-31-8

Alias TYA018, TYA 018

TYA-018 is an orally available and selective HDAC6 inhibitor with cardioprotective properties for the study of dilated heart disease and heart failure.TYA-018 prevents sarcomere damage and decreases Nppb expression.

TYA-018

🥰Excellent

Purity: 98.64%

Catalog No. T73464Alias TYA018, TYA 018Cas No. 2653254-31-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
5 mg	$64	In Stock	In Stock
10 mg	$93	In Stock	In Stock
25 mg	$148	In Stock	In Stock
50 mg	$223	In Stock	In Stock
100 mg	$392	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.64%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	TYA-018 is an orally available and selective HDAC6 inhibitor with cardioprotective properties for the study of dilated heart disease and heart failure.TYA-018 prevents sarcomere damage and decreases Nppb expression.
In vivo	In BAG3cKO mice, TYA-018 (15 mg/kg; oral gavage, daily, starting at 2 months old, for 8 weeks) conferred cardioprotection in mice. It significantly reduced Nppb expression to near wild-type levels.
Synonyms	TYA018, TYA 018

Chemical Properties

Molecular Weight	434.87
Formula	C₁₅H₁₃ClF₂N₄O₃S₂
Cas No.	2653254-31-8
Smiles	O=S(=O)(N(C=1C=CC=C(Cl)C1)CC2=NC=C(S2)C3=NN=C(O3)C(F)F)CC

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (183.96 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.59 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2995 mL	11.4977 mL	22.9954 mL	114.9769 mL
5 mM	0.4599 mL	2.2995 mL	4.5991 mL	22.9954 mL
10 mM	0.2300 mL	1.1498 mL	2.2995 mL	11.4977 mL
20 mM	0.1150 mL	0.5749 mL	1.1498 mL	5.7488 mL
50 mM	0.0460 mL	0.2300 mL	0.4599 mL	2.2995 mL
100 mM	0.0230 mL	0.1150 mL	0.2300 mL	1.1498 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc