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TYA-018

Name: TYA-018
Brand: TargetMol
SKU: T73464
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T73464Cas No. 2653254-31-8

Alias TYA018, TYA 018

TYA-018 is an orally available and selective HDAC6 inhibitor with cardioprotective properties for the study of dilated heart disease and heart failure.TYA-018 prevents sarcomere damage and decreases Nppb expression.

TYA-018

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Purity: 98.64%

Catalog No. T73464Alias TYA018, TYA 018Cas No. 2653254-31-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
5 mg	$64	In Stock	In Stock
10 mg	$93	In Stock	In Stock
25 mg	$148	In Stock	In Stock
50 mg	$223	In Stock	In Stock
100 mg	$392	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.64%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	TYA-018 is an orally available and selective HDAC6 inhibitor with cardioprotective properties for the study of dilated heart disease and heart failure.TYA-018 prevents sarcomere damage and decreases Nppb expression.
In vivo	In BAG3cKO mice, TYA-018 (15 mg/kg; oral gavage, daily, starting at 2 months old, for 8 weeks) conferred cardioprotection in mice. It significantly reduced Nppb expression to near wild-type levels.
Synonyms	TYA018, TYA 018

Chemical Properties

Molecular Weight	434.87
Formula	C₁₅H₁₃ClF₂N₄O₃S₂
Cas No.	2653254-31-8
Smiles	O=S(=O)(N(C=1C=CC=C(Cl)C1)CC2=NC=C(S2)C3=NN=C(O3)C(F)F)CC

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (183.96 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.59 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2995 mL	11.4977 mL	22.9954 mL	114.9769 mL
5 mM	0.4599 mL	2.2995 mL	4.5991 mL	22.9954 mL
10 mM	0.2300 mL	1.1498 mL	2.2995 mL	11.4977 mL
20 mM	0.1150 mL	0.5749 mL	1.1498 mL	5.7488 mL
50 mM	0.0460 mL	0.2300 mL	0.4599 mL	2.2995 mL
100 mM	0.0230 mL	0.1150 mL	0.2300 mL	1.1498 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc