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Talmapimod

Name: Talmapimod
Brand: TargetMol
SKU: T12871
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12871Cas No. 309913-83-5

Alias SCIO-469

Talmapimod (SCIO-469) is a selective, orally active, ATP-competitive p38α inhibitor with IC50 values of 9 nM for p38α and 90 nM for p38β. Talmapimod exhibits at least 2000-fold selectivity over a panel of 20 kinases, including other MAPKs.

Talmapimod

🥰Excellent

Purity: 99.9%

Catalog No. T12871Alias SCIO-469Cas No. 309913-83-5

Pack Size	Price	Availability
1 mg	$48	In Stock
2 mg	$70	In Stock
5 mg	$117	In Stock
10 mg	$187	In Stock
25 mg	$397	In Stock
50 mg	$589	In Stock
100 mg	$843	In Stock
1 mL x 10 mM (in DMSO)	$133	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.9%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Talmapimod (SCIO-469) is a selective, orally active, ATP-competitive p38α inhibitor with IC50 values of 9 nM for p38α and 90 nM for p38β. Talmapimod exhibits at least 2000-fold selectivity over a panel of 20 kinases, including other MAPKs.
Targets&IC50	p38α:9 nM, p38β:90 nM
In vitro	phosphorylation of p38 MAPK inhibited by Talmapimod (100-200 nM; 1 hour) in MM cells[1].In human whole blood, LPS-induced TNF-a production inhibited by Talmapimod [2]. Talmapimod decreases constitutive p38alpha MAPK phosphorylation of both 5T2MM and 5T33MM cells[3].
In vivo	Talmapimod (SCIO-469), targeting p38α MAPK, reduces myeloma burden and prevents myeloma bone disease[2]. In 5T2MM and 5T33MM models, it inhibits multiple myeloma growth and bone diseases[3]. Administered at 10-90 mg/kg orally, twice daily for 14 days, Talmapimod dose-dependently diminishes tumor growth and decreases the weight of palpable tumors at termination[4].
Synonyms	SCIO-469

Chemical Properties

Molecular Weight	513
Formula	C₂₇H₃₀ClFN₄O₃
Cas No.	309913-83-5
Smiles	C[C@H]1CN([C@H](C)CN1Cc1ccc(F)cc1)C(=O)c1cc2c(cn(C)c2cc1Cl)C(=O)C(=O)N(C)C
Relative Density.	1.29 g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 95 mg/mL (185.19 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9493 mL	9.7466 mL	19.4932 mL	97.4659 mL
5 mM	0.3899 mL	1.9493 mL	3.8986 mL	19.4932 mL
10 mM	0.1949 mL	0.9747 mL	1.9493 mL	9.7466 mL
20 mM	0.0975 mL	0.4873 mL	0.9747 mL	4.8733 mL
50 mM	0.0390 mL	0.1949 mL	0.3899 mL	1.9493 mL
100 mM	0.0195 mL	0.0975 mL	0.1949 mL	0.9747 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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