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Synonyms: FGFR1 α (IIIc), FGFR1 α, FGFR1 alpha, FGF R1a

| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 µg | $32 | 7-10 days | 7-10 days | |
| 10 µg | $48 | 7-10 days | 7-10 days | |
| 20 µg | $74 | 7-10 days | 7-10 days | |
| 50 µg | $138 | 7-10 days | 7-10 days | |
| 100 µg | $231 | 7-10 days | 7-10 days | |
| 200 µg | $419 | 7-10 days | 7-10 days | |
| 500 µg | $932 | 7-10 days | 7-10 days |
| Bioactivity | Immobilized Human FGFR1 alpha (IIIc), His Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for Biotinylated Human FGF1, His Avi Tag with the EC50 of 98.7ng/ml determined by ELISA. (QC Test) Immobilized Human FGFR1 alpha (IIIc), His Tag at 0.5 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-FGFR1 Antibody, hFc Tag with the EC50 of 4.8 ng/ml determined by ELISA. |
| Description | FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 40.74 kDa and the accession number is P11362-7. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | C-His |
| Accession Number | P11362-7 |
| Construction | Arg22-Glu374 |
| Protein Purity | > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS (pH 7.4). Typically, 8% trehalose is incorporated as a protective agent before lyophilization. |
| Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Synonyms | FGFR1 α (IIIc), FGFR1 α, FGFR1 alpha, FGF R1a |
| Research Background | Fibroblast growth factors (FGFs) comprise a family of at least eighteen structurally related proteins that are involved in a multitude of physiological and pathological cellular processes, including cell growth, differentiation, angiogenesis, wound healing and tumorgenesis. The biological activities of the FGFs are mediated by a family of type I transmembrane tyrosine kinases which undergo dimerization and autophosphorylation after ligand binding.FGFR1 is tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. |
| Molecular Weight | 40.74 kDa (predicted), 65-80 kDa (due to glycosylation) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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