Shopping Cart

Your shopping cart is currently empty

Liquiritin

Name: Liquiritin
Brand: TargetMol
SKU: T2899
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T2899Cas No. 551-15-5

Alias Liquiritoside, Liquiritigenin-4'-O-glucoside

Liquiritin (Liquiritigenin-4'-O-glucoside) (LIQ) is a main component among the licorice flavonoids, and possesses anti-inflammatory and anti-cancer abilities.

Liquiritin

Copy Product Info

😃Good

Purity: 98.66%

Catalog No. T2899Alias Liquiritoside, Liquiritigenin-4'-O-glucosideCas No. 551-15-5

Liquiritin (Liquiritigenin-4'-O-glucoside) (LIQ) is a main component among the licorice flavonoids, and possesses anti-inflammatory and anti-cancer abilities.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$39	In Stock	In Stock
10 mg	$64	In Stock	In Stock
25 mg	$128	In Stock	In Stock
50 mg	$198	In Stock	In Stock
100 mg	$328	In Stock	In Stock
500 mg	$788	-	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:98.66%

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Liquiritin AI Summary

Liquiritin exhibits a diverse range of bioactivities. It inhibits cow milk xanthine oxidase with an inhibition rate of 18.0% at a concentration of 50 µg/mL. The compound shows inhibition of neuraminidase activity in various Influenza A strains, including the Spanish flu strain A/Bervig_Mission/1/18, with an IC50 value of 82,300.0 nM and a noncompetitive inhibition Ki value of 123,700.0 nM. Additionally, Liquiritin demonstrates inhibitory activities against enzymes such as AmpC Beta-Lactamase, BAZ2B, ELG1-dependent DNA repair, Polymerase Iota, Protein Disulfide Isomerase, and MBNL1-poly(CUG) RNA binding. It shows cytotoxicity against MDCK cells with a CC50 greater than 239,000.0 nM and inhibits neuraminidase of oseltamivir-resistant Influenza A virus H1N1 B/55/08 with an IC50 of 140,000.0 nM and Influenza A virus A/Puerto Rico/8/1934(H1N1) with an IC50 of 83,100.0 nM. The compound exhibits modulatory effects on miRNAs, particularly on miR-21, and shows promising activity in re-activating p53, acting as a general anesthetic, and in beta-arrestin-biased ligand assays for beta2-adrenergic receptor. Furthermore, Liquiritin selectively kills Giardia lamblia, inhibits Marburg Virus entry, induces DNA re-replication in normal breast cells, and has shown antitussive and expectorant activities in ICR mice. However, it exhibits less than 50% inhibition on PTP1B activity at 100 µM concentration..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Liquiritin (Liquiritigenin-4'-O-glucoside) (LIQ) is a main component among the licorice flavonoids, and possesses anti-inflammatory and anti-cancer abilities.
Targets&IC50	AKR1C3:3.72μM (IC50), AKR1C2:0.61 μM (IC50), AKR1C1:0.62 μM (IC50)
Synonyms	Liquiritoside, Liquiritigenin-4'-O-glucoside

Chemical Properties

Molecular Weight	418.39
Formula	C₂₁H₂₂O₉
Cas No.	551-15-5
Smiles	OC[C@H]1O[C@@H](Oc2ccc(cc2)[C@@H]2CC(=O)c3ccc(O)cc3O2)[C@H](O)[C@@H](O)[C@@H]1O
Relative Density.	1.529g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (358.52 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (9.56 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3901 mL	11.9506 mL	23.9011 mL	119.5057 mL
5 mM	0.4780 mL	2.3901 mL	4.7802 mL	23.9011 mL
10 mM	0.2390 mL	1.1951 mL	2.3901 mL	11.9506 mL
20 mM	0.1195 mL	0.5975 mL	1.1951 mL	5.9753 mL
50 mM	0.0478 mL	0.2390 mL	0.4780 mL	2.3901 mL
100 mM	0.0239 mL	0.1195 mL	0.2390 mL	1.1951 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc