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Soquelitinib
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Catalog No. T87429Cas No. 2226636-04-8
Alias CPI-818, CPI818
Soquelitinib (CPI-818) is a covalent, irreversible, oral and selective ITK inhibitor that preferentially inhibits Th2 cytokine production over Th1, inhibits in vivo tumor growth in mice, and decreases markers of T-cell exhaustion, resulting in an increase in tumor infiltration and up-regulation of CXCR3, IFNγ, TNFα, and CD107a expression in normal CD8 cells.
Soquelitinib
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Purity: 99.54%
Catalog No. T87429Alias CPI-818, CPI818Cas No. 2226636-04-8
Soquelitinib (CPI-818) is a covalent, irreversible, oral and selective ITK inhibitor that preferentially inhibits Th2 cytokine production over Th1, inhibits in vivo tumor growth in mice, and decreases markers of T-cell exhaustion, resulting in an increase in tumor infiltration and up-regulation of CXCR3, IFNγ, TNFα, and CD107a expression in normal CD8 cells.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $165 | In Stock | In Stock | |
| 5 mg | $413 | In Stock | In Stock | |
| 10 mg | $679 | In Stock | In Stock | |
| 25 mg | $1,350 | In Stock | In Stock | |
| 50 mg | $1,980 | In Stock | In Stock | |
| 100 mg | $2,890 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $468 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
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Purity:99.54%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Soquelitinib (CPI-818) is a covalent, irreversible, oral and selective ITK inhibitor that preferentially inhibits Th2 cytokine production over Th1, inhibits in vivo tumor growth in mice, and decreases markers of T-cell exhaustion, resulting in an increase in tumor infiltration and up-regulation of CXCR3, IFNγ, TNFα, and CD107a expression in normal CD8 cells. |
| Targets&IC50 | IL-2 secretion (Jurkat T cells):136 nM |
| In vitro | In Jurkat T cells, Soquelitinib inhibits downstream TCR signaling (e.g., phosphorylation of PLCγ1 and ERK) and suppresses IL-2 secretion (IC₅₀ = 136 nM). Soquelitinib downregulates Th2 cytokines (IL-4, IL-5, IL-13) and promotes Th1 skewing. In repeatedly stimulated human CD8 T cells, 1 μM soquelitinib reduces exhaustion markers (PD1, LAG3, TIGIT, Tim3) and restores effector functions, increasing IFNγ and Granzyme B levels[1]. |
| In vivo | Oral administration of soquelitinib (30 mg/kg, b.i.d.) significantly inhibited tumor growth in multiple murine tumor models (CT26, RENCA, B16F10, EL4, A20). Soquelitinib enhanced CD8+ T-cell infiltration and cytotoxic activity (e.g., increased IFNγ, TNF, Perforin). Combined treatment with anti-PD-1 or CTLA-4 antibodies showed synergistic effects, with complete tumor regression in some cases and reduced expression of exhaustion markers in TILs. Long-term oral dosing in rats showed no observable toxicity (NOAEL >1000 mg/kg)[1]. |
| Synonyms | CPI-818, CPI818 |
| Molecular Weight | 514.66 |
| Formula | C25H30N4O4S2 |
| Cas No. | 2226636-04-8 |
| Smiles | C(=O)(C1=C(OC)C=C(C)C(SC=2SC(NC(=O)C3CC3)=NC2)=C1)N4C[C@@H](C)N(C(C=C)=O)CCC4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (155.44 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 10 mg/mL (19.43 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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