Shopping Cart

Remove All
Your shopping cart is currently empty

Proceed to checkout Continue shopping

Chromatin/Epigenetic

DNA Methyltransferase

(45)

Epigenetic Reader Domain

HIF/HIF Prolyl-Hydroxylase

(82)

Histone Acetyltransferase

(51)

Histone Demethylase

(96)

Histone Methyltransferase

Methionine Adenosyltransferase (MAT)

Histone Methyltransferase

Histone methyltransferases (HMT) are histone-modifying enzymes , that catalyze the transfer of one, two, or three methyl groups to lysine and arginine residues of histone proteins. The attachment of methyl groups occurs predominantly at specific lysine or arginine residues on histones H3 and H4.

Filter HomeSignaling PathwaysChromatin/EpigeneticHistone Methyltransferase

MAK-683 hydrochloride

T96812170606-94-5In house

MAK683 hydrochloride embryonic ectodermal development (EED) inhibitor, also a potent PRC2 inhibitor, blocked cancer cell proliferation (IC50=1.014nM), with IC50 values of 59, 26, and 89 nM measured in EED Alphascreen, ELISA, and LC-MS assays, respectively.

$195

In Stock

Size

QTY

SNDX-5613

T129432169919-21-3

Revumenib (SNDX-5613) is a potent and selective oral inhibitor of menin-KMT2A interaction with Ki of 0.149 nM and IC50 between 10 and 20 nM, which can be used in the study of acute leukemia with MLL gene rearrangement.

In Stock

Size

QTY

EPZ031686

TQ02631808011-22-4

EPZ031686 is an effective inhibitor of SMYD3 inhibitor with an IC50 of 3 nM and can be used in studies about cancer.

$113

In Stock

Size

QTY

SETDB1-TTD-IN-1

T97422755823-12-0In house

SETDB1-TTD-IN-1 is a potent and selective inhibitor of SET domain bifurcated protein 1 tandem tudor domain (SETDB1-TTD, Kd = 88 nM), and also an endogenous binder competitive inhibitor with a KD of 0.106±0.002 μM for TTD. It can be used to study the biological functions and disease associations of SETDB1-TTD.

$269

In Stock

Size

QTY

Sinefungin

T1688658944-73-3In house

Sinefungin (Adenosyl-Ornithine) is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication. Sinefungin is a SET7 9 inhibitor and ameliorates renal fibrosis by inhibiting H3K4 methylation.

$222

In Stock

Size

QTY

VTP50469

T133362169916-18-9

VTP50469 is a highly selective and orally active small molecule inhibitor of the Menin-MLL protein-protein interaction with potent anti-leukemic activity with a Ki of 104 pM.

$176

In Stock

Size

QTY

GSK126

T20791346574-57-9

GSK126 (GSK2816126A) is a excellently specific EZH2 methyltransferase inhibitor ( IC50=9.9 nM).

In Stock

Size

QTY

Tulmimetostat

T401992567686-02-4

Tulmimetostat (CPI-0209) is an orally active EZH1/EZH2 inhibitor with antitumor activity, utilized in the study of ovarian cancer and advanced solid tumors.

In Stock

Size

QTY

MU1656

T639552766698-38-6In house

MU1656 is a potent and selective inhibitor of histone methyltransferase DOT1L (IC50 = 2 nM), a key epigenetic regulatory protein involved in the development of cancers such as hematologic malignancies, thus MU1656 was able to significantly inhibit the proliferation of cancer cells and induce apoptosis.

$2,390

In Stock

Size

QTY

EZM 2302

T56051628830-21-6

EZM 2302 (GSK3359088) is a selective, and orally available arginine methyltransferase CARM1 inhibitor (IC50: 6 nM).[1]

In Stock

Size

QTY

LLY-507

T68791793053-37-8

LLY-507 is an effective, cell-active, and specific inhibitor of protein-lysine Methyltransferase SMYD2.

In Stock

Size

QTY

TP-064

T289962080306-20-1

TP-064 is a potent and selective PRMT4 inhibitor, featuring an IC50 < 10nM for methylation of H3 (1-25) and over 100-fold selectivity compared to other histone methyltransferases and non-epigenetic targets. It inhibits the methylation of MED12 in cells with an IC50 of 43 nM.

In Stock

Size

QTY

Pinometostat

T30991380288-87-8

Pinometostat (EPZ-5676) is a potent DOT1L histone methyltransferase inhibitor (Ki=80 pM). Pinometostat has antitumor activity and can be used in experiments to study a variety of leukemia treatments.

In Stock

Size

QTY

CM-272

T71941846570-31-7

CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.

In Stock

Size

QTY

OICR-9429

T69161801787-56-3

OICR-9429 is a potent antagonist of the interaction that WDR5 effect with peptide regions of MLL and Histone 3. It reduces the viability of acute myeloid leukemia cells in vitro.

In Stock

Size

QTY

GSK467

T54841628332-52-4

GSK467 is a potent and selective inhibitor of KDM5 (JARID1)(Ki : 10 nM).

In Stock

Size

QTY

EZM0414

T99692411748-50-8

EZM0414 is a potent and selective, orally bioavailable inhibitor of SETD2 with an IC50 of 18 nM in biochemical assays and 34 nM in cellular assays, potentially useful for researching relapsed or refractory multiple myeloma and diffuse large B-cell lymphoma [1].

$279

In Stock

Size

QTY

3-deazaneplanocin A HCl

T6360120964-45-6

3-deazaneplanocin A (DZNeP)HCl, an analog of adenosine, is a competitive inhibitor of S-adenosylhomocysteine hydrolase with Ki of 50 pM.

In Stock

Size

QTY

WM-3835

T91022229025-70-9

WM-3835 is a novel and high-specific small molecule inhibitor of Lysine Acetyltransferase 7 (KAT7, MYST2, HBO1) , able to potently suppressed OS cell proliferation and migration, and leads to apoptosis activation.

In Stock

Size

QTY

Ziftomenib

T395852134675-36-6

Ziftomenib (KO-539) is an inhibitor of menin-MLL interaction with antitumor activity, suitable for leukemia research.

$115

In Stock

Size

QTY

EZH2-IN-15

T678832098545-98-1

EZH2-IN-15 (SHR2554) is a specific inhibitor of the zeste 2 histone modification enhancer (EZH2).EZH2 is aberrantly overexpressed in many human cancers and controls adaptive responses by regulating Treg activity. EZH2 expression in tumors has also been shown to control innate immunity.

$159

In Stock

Size

QTY

EPZ015666

T60761616391-65-1

EPZ015666 (GSK3235025) is an orally available inhibitor of PRMT5 enzymatic activity.

In Stock

Size

QTY

(Iso)-MS4322

T402332601727-80-2In house

(Iso)-MS4322 ((Iso)-YS43-22) is a selective and potent protein arginine methyltransferase 5 (PRMT5) degrader with potential anticancer activity that effectively reduces PRMT5 protein levels in MCF-7 cells and inhibits the growth of a wide range of cancer cells.

$489

In Stock

Size

QTY

Chaetocin

T680328097-03-2

Chaetocin, a natural product from Chaetomium species, is a histone methyltransferase inhibitor with IC50 of 0.8 μM, 2.5 μM and 3 μM for dSU(VAR)3-9, mouse G9a and Neurospora crassa DIM5, respectively.

$129

In Stock

Size

QTY

Go to page 1

Page of 4