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Psora 4

Name: Psora 4
Brand: TargetMol
SKU: T21819
Rating: 4.5 (1 reviews)

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Catalog No. T21819Cas No. 724709-68-6

Alias 5-(4-Phenylbutoxy)psoralen

Psora 4 (5-(4-Phenylbutoxy)psoralen) is a selective and potent Kv1.3 blocker, a caloric restriction mimetic with immunosuppressive activity that enhances neural progenitor cell differentiation and maturation.

Psora 4

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Catalog No. T21819Alias 5-(4-Phenylbutoxy)psoralenCas No. 724709-68-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$150	35 days	35 days
5 mg	Inquiry	35 days	35 days
10 mg	Inquiry	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	Psora 4 (5-(4-Phenylbutoxy)psoralen) is a selective and potent Kv1.3 blocker, a caloric restriction mimetic with immunosuppressive activity that enhances neural progenitor cell differentiation and maturation.
Targets&IC50	myelin-specific effector memory T cells (human):25 nM （EC50）, Kv1.3 channel:3 nM （EC50）, myelin-specific effector memory T cells (rat):60 nM （EC50）, Kv1.5 channel:7.7 nM （EC50）
In vitro	Psora 4 blocks Kv1.3 in a dose-dependent manner by preferentially binding to the C-type inactivation state of the channel with an EC50 value of 3 nM.Psora 4 is the most potent small molecule Kv1.3 blocker known. It is 17- to 70-fold more selective for Kv1.3 than the closely related Kv1 family of channels (Kv1.1, Kv1.2, Kv1.4, and Kv1.7), with the exception of Kv1.5, which is selective for Kv1.5 (EC50 of 7.7 nM). Psora 4 selectively inhibits the proliferation of human and rat myelin-specific effector memory T cells with EC50 values of 25 and 60 nM, respectively, but does not persistently inhibit peripheral blood naïve and central memory T cells. [1]
In vivo	In an in vivo rat toxicity assay, 33 mg/kg Psora 4 administered subcutaneously five times daily did not show any signs of acute toxicity. [1]
Synonyms	5-(4-Phenylbutoxy)psoralen

Chemical Properties

Molecular Weight	334.37
Formula	C₂₁H₁₈O₄
Cas No.	724709-68-6
Smiles	O=C1OC=2C=C3OC=CC3=C(OCCCCC=4C=CC=CC4)C2C=C1
Relative Density.	1.246g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 8 mg/mL (23.93 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9907 mL	14.9535 mL	29.9070 mL	149.5349 mL
5 mM	0.5981 mL	2.9907 mL	5.9814 mL	29.9070 mL
10 mM	0.2991 mL	1.4953 mL	2.9907 mL	14.9535 mL
20 mM	0.1495 mL	0.7477 mL	1.4953 mL	7.4767 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc