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QX-314 bromide
🥰Excellent
Catalog No. T16707Cas No. 24003-58-5
QX-314 bromide is a membrane-impermeable sodium channel blocker that inhibits TRPV1 and NaV1.8 expression, causing sensory-selective blockade of TRPV1 channels. It exhibits anti-inflammatory effects and may be used in studies of gastroesophageal reflux disease (GERD).
QX-314 bromide
🥰Excellent
Purity: 99.05%
Catalog No. T16707Cas No. 24003-58-5
QX-314 bromide is a membrane-impermeable sodium channel blocker that inhibits TRPV1 and NaV1.8 expression, causing sensory-selective blockade of TRPV1 channels. It exhibits anti-inflammatory effects and may be used in studies of gastroesophageal reflux disease (GERD).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $39 | - | In Stock | |
| 5 mg | $90 | - | In Stock | |
| 10 mg | $129 | - | In Stock | |
| 25 mg | $219 | - | In Stock | |
| 50 mg | $323 | - | In Stock | |
| 100 mg | $483 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $97 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.05%
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Product Introduction
Bioactivity
Chemical Properties
| Description | QX-314 bromide is a membrane-impermeable sodium channel blocker that inhibits TRPV1 and NaV1.8 expression, causing sensory-selective blockade of TRPV1 channels. It exhibits anti-inflammatory effects and may be used in studies of gastroesophageal reflux disease (GERD). |
| In vitro | QX-314 bromide (1-60 mM) can directly activate TRPV1 channels in a concentration-dependent manner [1]. QX-314 bromide (≥30 mM) causes darkening of the oocyte membrane and induces cell death [1]. |
| In vivo | QX-314 bromide (0.2%, 10 μl, 1.6 mg/kg, plantar injection) combined with 1% lidocaine significantly prolonged the response latency to thermal and mechanical stimuli in rats [2]. QX-314 bromide (0.2%, intradermal injection) combined with 1% lidocaine completely suppressed the cutaneous trunci muscle reflex (CTMR) evoked by needle stimulation in rats, with a blockade duration of up to 6 hours [2]. QX-314 bromide (0.2%, perisciatic injection) combined with varying concentrations of lidocaine (0.5%-2%) produced dose-dependent long-lasting nociceptive blockade [2]. |
| Molecular Weight | 343.3 |
| Formula | C16H27BrN2O |
| Cas No. | 24003-58-5 |
| Smiles | [Br-].O=C(NC=1C(=CC=CC1C)C)C[N+](CC)(CC)CC |
| Relative Density. | no data available |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (116.52 mM), Sonication is recommended. H2O: 80 mg/mL (233.03 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/H2O
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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