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QX-314 bromide

Name: QX-314 bromide
Brand: TargetMol
SKU: T16707
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16707Cas No. 24003-58-5

QX-314 bromide is a membrane-impermeable sodium channel blocker that inhibits TRPV1 and NaV1.8 expression, causing sensory-selective blockade of TRPV1 channels. It exhibits anti-inflammatory effects and may be used in studies of gastroesophageal reflux disease (GERD).

QX-314 bromide

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Purity: 99.05%

Catalog No. T16707Cas No. 24003-58-5

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$30	-	In Stock
50 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.05%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	QX-314 bromide is a membrane-impermeable sodium channel blocker that inhibits TRPV1 and NaV1.8 expression, causing sensory-selective blockade of TRPV1 channels. It exhibits anti-inflammatory effects and may be used in studies of gastroesophageal reflux disease (GERD).
In vitro	QX-314 bromide (1-60 mM) can directly activate TRPV1 channels in a concentration-dependent manner [1]. QX-314 bromide (≥30 mM) causes darkening of the oocyte membrane and induces cell death [1].
In vivo	QX-314 bromide (0.2%, 10 μl, 1.6 mg/kg, plantar injection) combined with 1% lidocaine significantly prolonged the response latency to thermal and mechanical stimuli in rats [2]. QX-314 bromide (0.2%, intradermal injection) combined with 1% lidocaine completely suppressed the cutaneous trunci muscle reflex (CTMR) evoked by needle stimulation in rats, with a blockade duration of up to 6 hours [2]. QX-314 bromide (0.2%, perisciatic injection) combined with varying concentrations of lidocaine (0.5%-2%) produced dose-dependent long-lasting nociceptive blockade [2].

Chemical Properties

Molecular Weight	343.3
Formula	C₁₆H₂₇BrN₂O
Cas No.	24003-58-5
Smiles	[Br-].O=C(NC=1C(=CC=CC1C)C)C[N+](CC)(CC)CC
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (116.52 mM), Sonication is recommended.

H2O: 80 mg/mL (233.03 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (5.83 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.9129 mL	14.5645 mL	29.1290 mL	145.6452 mL
5 mM	0.5826 mL	2.9129 mL	5.8258 mL	29.1290 mL
10 mM	0.2913 mL	1.4565 mL	2.9129 mL	14.5645 mL
20 mM	0.1456 mL	0.7282 mL	1.4565 mL	7.2823 mL
50 mM	0.0583 mL	0.2913 mL	0.5826 mL	2.9129 mL
100 mM	0.0291 mL	0.1456 mL	0.2913 mL	1.4565 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc