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QX-314 bromide

Name: QX-314 bromide
Brand: TargetMol
SKU: T16707
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16707Cas No. 24003-58-5

QX-314 bromide is a membrane-impermeable sodium channel blocker that inhibits TRPV1 and NaV1.8 expression, causing sensory-selective blockade of TRPV1 channels. It exhibits anti-inflammatory effects and may be used in studies of gastroesophageal reflux disease (GERD).

QX-314 bromide

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Purity: 99.05%

Catalog No. T16707Cas No. 24003-58-5

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$30	-	In Stock
50 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.05%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	QX-314 bromide is a membrane-impermeable sodium channel blocker that inhibits TRPV1 and NaV1.8 expression, causing sensory-selective blockade of TRPV1 channels. It exhibits anti-inflammatory effects and may be used in studies of gastroesophageal reflux disease (GERD).
In vitro	QX-314 bromide (1-60 mM) can directly activate TRPV1 channels in a concentration-dependent manner [1]. QX-314 bromide (≥30 mM) causes darkening of the oocyte membrane and induces cell death [1].
In vivo	QX-314 bromide (0.2%, 10 μl, 1.6 mg/kg, plantar injection) combined with 1% lidocaine significantly prolonged the response latency to thermal and mechanical stimuli in rats [2]. QX-314 bromide (0.2%, intradermal injection) combined with 1% lidocaine completely suppressed the cutaneous trunci muscle reflex (CTMR) evoked by needle stimulation in rats, with a blockade duration of up to 6 hours [2]. QX-314 bromide (0.2%, perisciatic injection) combined with varying concentrations of lidocaine (0.5%-2%) produced dose-dependent long-lasting nociceptive blockade [2].

Chemical Properties

Molecular Weight	343.3
Formula	C₁₆H₂₇BrN₂O
Cas No.	24003-58-5
Smiles	[Br-].O=C(NC=1C(=CC=CC1C)C)C[N+](CC)(CC)CC
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (116.52 mM), Sonication is recommended.

H2O: 80 mg/mL (233.03 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (5.83 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.9129 mL	14.5645 mL	29.1290 mL	145.6452 mL
5 mM	0.5826 mL	2.9129 mL	5.8258 mL	29.1290 mL
10 mM	0.2913 mL	1.4565 mL	2.9129 mL	14.5645 mL
20 mM	0.1456 mL	0.7282 mL	1.4565 mL	7.2823 mL
50 mM	0.0583 mL	0.2913 mL	0.5826 mL	2.9129 mL
100 mM	0.0291 mL	0.1456 mL	0.2913 mL	1.4565 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc