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Quindoxin
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Catalog No. T212594Cas No. 2423-66-7
Quindoxin is a potent antibacterial agent that has been rigorously evaluated for genetic toxicity using the Salmonella microsomal assay system, where experimental testing demonstrated that this compound induces both base pair substitution mutations and frameshift mutations in Salmonella strains independently of the presence of a rat liver microsomal fraction, with mutagenic activity shown to be mechanistically dependent on the presence of its N-oxide functional group, as fully reduced quinoxaline lacked mutagenicity while partially reduced quinoxaline-N-oxide displayed diminished activity, and recA- and uvrB-deficient Salmonella strains exhibited increased susceptibility compared with wild-type strains.
Quindoxin
😃Good
Purity: 95%
Catalog No. T212594Cas No. 2423-66-7
Quindoxin is a potent antibacterial agent that has been rigorously evaluated for genetic toxicity using the Salmonella microsomal assay system, where experimental testing demonstrated that this compound induces both base pair substitution mutations and frameshift mutations in Salmonella strains independently of the presence of a rat liver microsomal fraction, with mutagenic activity shown to be mechanistically dependent on the presence of its N-oxide functional group, as fully reduced quinoxaline lacked mutagenicity while partially reduced quinoxaline-N-oxide displayed diminished activity, and recA- and uvrB-deficient Salmonella strains exhibited increased susceptibility compared with wild-type strains.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $35 | - | In Stock | |
| 5 mg | $78 | - | In Stock | |
| 10 mg | $117 | - | In Stock | |
| 25 mg | $198 | - | In Stock | |
| 50 mg | $298 | - | In Stock | |
| 100 mg | $447 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:95%
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Quindoxin is a potent antibacterial agent that has been rigorously evaluated for genetic toxicity using the Salmonella microsomal assay system, where experimental testing demonstrated that this compound induces both base pair substitution mutations and frameshift mutations in Salmonella strains independently of the presence of a rat liver microsomal fraction, with mutagenic activity shown to be mechanistically dependent on the presence of its N-oxide functional group, as fully reduced quinoxaline lacked mutagenicity while partially reduced quinoxaline-N-oxide displayed diminished activity, and recA- and uvrB-deficient Salmonella strains exhibited increased susceptibility compared with wild-type strains. |
| Molecular Weight | 162.15 |
| Formula | C8H6N2O2 |
| Cas No. | 2423-66-7 |
| Smiles | O=N=1C=CN(=O)=C2C=CC=CC21 |
| Color | Yellow |
| Appearance | Solid |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 10 mg/mL (61.67 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyThe above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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