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10-DEBC hydrochloride

Name: 10-DEBC hydrochloride
Brand: TargetMol
SKU: T21778
Price: 68 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21778Cas No. 925681-41-0

10-DEBC hydrochloride is a selective Akt inhibitor with an IC50 value of 1.28 μM that has also been identified as a novel anti-tuberculosis research compound, supporting investigations into Akt signaling modulation, host–pathogen interactions, and therapeutic strategies targeting kinase-regulated survival pathways in infectious disease models.

10-DEBC hydrochloride

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Purity: 99.99%

Catalog No. T21778Cas No. 925681-41-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$68	-	In Stock
5 mg	$163	-	In Stock
10 mg	$263	-	In Stock
25 mg	$446	-	In Stock
50 mg	$645	-	In Stock
100 mg	$886	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.99%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	10-DEBC hydrochloride is a selective Akt inhibitor with an IC50 value of 1.28 μM that has also been identified as a novel anti-tuberculosis research compound, supporting investigations into Akt signaling modulation, host–pathogen interactions, and therapeutic strategies targeting kinase-regulated survival pathways in infectious disease models.
Targets&IC50	Akt:1.28 μM
In vitro	Method: Structure-based virtual screening of the LOPAC library was followed by Pim1 kinase enzymatic assays and cocrystal structure determination with identified hits. Result: Thioridazine and 10-DEBC hydrochloride were identified as low-micromolar Pim1 kinase inhibitors, and structural analysis defined key pharmacophore features underlying Pim1 inhibition[1].

Chemical Properties

Molecular Weight	381.34
Formula	C₂₀H₂₆Cl₂N₂O
Cas No.	925681-41-0
Smiles	Cl.ClC1=CC=C2OC=3C=CC=CC3N(C2=C1)CCCCN(CC)CC
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (209.79 mM), Sonication is recommended.

H2O: 40 mg/mL (104.89 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6223 mL	13.1117 mL	26.2233 mL	131.1166 mL
5 mM	0.5245 mL	2.6223 mL	5.2447 mL	26.2233 mL
10 mM	0.2622 mL	1.3112 mL	2.6223 mL	13.1117 mL
20 mM	0.1311 mL	0.6556 mL	1.3112 mL	6.5558 mL
50 mM	0.0524 mL	0.2622 mL	0.5245 mL	2.6223 mL
100 mM	0.0262 mL	0.1311 mL	0.2622 mL	1.3112 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc