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2-Fluoropalmitic acid

Name: 2-Fluoropalmitic acid
Brand: TargetMol
SKU: T21842
Rating: 4.5 (1 reviews)

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Catalog No. T21842Cas No. 16518-94-8

Alias 2-Fluorohexadecanoic acid

2-Fluoropalmitic acid (2-Fluorohexadecanoic acid), a fatty acid containing fluorine atoms, serves as a potential therapeutic agent for glioblastoma (GBM) by inhibiting the viability, proliferation, and stem-like phenotype of glioma stem cells (GSCs), suppressing the expression of phosphorylated erk, CD133, and SOX-2, and leading to decreased MMP-2 activity and increased methylation of the MGMT promoter.

2-Fluoropalmitic acid

😃Good

Catalog No. T21842Alias 2-Fluorohexadecanoic acidCas No. 16518-94-8

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$626	6-8 weeks	6-8 weeks
50 mg	$814	6-8 weeks	6-8 weeks
100 mg	$1,230	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	2-Fluoropalmitic acid (2-Fluorohexadecanoic acid), a fatty acid containing fluorine atoms, serves as a potential therapeutic agent for glioblastoma (GBM) by inhibiting the viability, proliferation, and stem-like phenotype of glioma stem cells (GSCs), suppressing the expression of phosphorylated erk, CD133, and SOX-2, and leading to decreased MMP-2 activity and increased methylation of the MGMT promoter.
In vitro	After incubating 2-Fluoropalmitic acid with human leukemia cell lines (such as MOLT-4) and normal fibroblasts (HDF cells), cell viability was assessed using the MTT assay, and apoptosis was observed by flow cytometry or fluorescence microscopy. The Results showed that 2-Fluoropalmitic acid (concentration range of 12.5-50 μg/ml) exhibited significant cytotoxicity against human leukemia cell lines (such as MOLT-4), but had no obvious toxicity to normal fibroblasts (HDF cells), with minimal impact on normal cells, while it was able to induce apoptosis in cancer cells[1].
Synonyms	2-Fluorohexadecanoic acid

Chemical Properties

Molecular Weight	274.41
Formula	C₁₆H₃₁FO₂
Cas No.	16518-94-8
Smiles	O=C(O)C(F)CCCCCCCCCCCCCC
Relative Density.	0.936g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (291.53 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (12.03 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6442 mL	18.2209 mL	36.4418 mL	182.2091 mL
5 mM	0.7288 mL	3.6442 mL	7.2884 mL	36.4418 mL
10 mM	0.3644 mL	1.8221 mL	3.6442 mL	18.2209 mL
20 mM	0.1822 mL	0.9110 mL	1.8221 mL	9.1105 mL
50 mM	0.0729 mL	0.3644 mL	0.7288 mL	3.6442 mL
100 mM	0.0364 mL	0.1822 mL	0.3644 mL	1.8221 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc