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Flaviviruses-IN-2

Name: Flaviviruses-IN-2
Brand: TargetMol
SKU: T72041
Price: 147 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T72041Cas No. 1009762-84-8

Flaviviruses-IN-2 is a potent flaviviruses inhibitor. Flaviviruses-IN-2 reduces West Nile virus (WNV) protease activity and inhibits WNV by 56%.

Flaviviruses-IN-2

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Purity: 99.56%

Catalog No. T72041Cas No. 1009762-84-8

Flaviviruses-IN-2 is a potent flaviviruses inhibitor. Flaviviruses-IN-2 reduces West Nile virus (WNV) protease activity and inhibits WNV by 56%.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$147	In Stock	In Stock
5 mg	$348	In Stock	In Stock
10 mg	$475	In Stock	In Stock
25 mg	$667	In Stock	In Stock
50 mg	$887	In Stock	In Stock
100 mg	$1,220	In Stock	In Stock
200 mg	$1,630	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.56%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Flaviviruses-IN-2 AI Summary

Flaviviruses-IN-2 exhibits a range of bioactivities across various biological targets. It shows significant potency as an inhibitor of Cruzain enzyme activity with an IC50 value of 7943.3 nM. Additionally, it inhibits Tau fibril formation with an IC50 of 39810.7 nM, and targets the Menin-MLL interaction in MLL-related leukemias by competing with a Texas Red labeled MLL-derived mutant peptide, demonstrating an IC50 of 17782.8 nM. Flaviviruses-IN-2 also inhibits the binding or entry of Marburg Virus into cells with an IC50 of 562.3 nM and functions as a GLP-1 receptor inverse agonist with an IC50 of 10000.0 nM. Furthermore, it acts as an agonist for the gsp mutation associated with fibrous dysplasia/McCune-Albright Syndrome, with a potency of 12589.3 nM, and serves as an inhibitor of human tyrosyl-DNA phosphodiesterase 1 (TDP1) in cells in the absence of CPT with an IC50 of 29092.9 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Flaviviruses-IN-2 is a potent flaviviruses inhibitor. Flaviviruses-IN-2 reduces West Nile virus (WNV) protease activity and inhibits WNV by 56%.

Chemical Properties

Molecular Weight	380.46
Formula	C₂₁H₂₀N₂O₃S
Cas No.	1009762-84-8
Smiles	C(C(NC1=CC=C(OC)C=C1)=O)(NC(CC2=CC=CS2)=O)C3=CC=CC=C3
Relative Density.	1.280 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (131.42 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6284 mL	13.1420 mL	26.2840 mL	131.4199 mL
5 mM	0.5257 mL	2.6284 mL	5.2568 mL	26.2840 mL
10 mM	0.2628 mL	1.3142 mL	2.6284 mL	13.1420 mL
20 mM	0.1314 mL	0.6571 mL	1.3142 mL	6.5710 mL
50 mM	0.0526 mL	0.2628 mL	0.5257 mL	2.6284 mL
100 mM	0.0263 mL	0.1314 mL	0.2628 mL	1.3142 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc