Shopping Cart
- Remove All
Your shopping cart is currently empty
Anti-ER alpha Antibody (5U584)
😃Good
Catalog No. TMAH-00406
Alias Nuclear Receptor Subfamily 3 Group A Member 1, NR3A1, estrogen receptor α, estrogen receptor alpha, Estrogen Receptor, Estradiol Receptor, ESR1, ESR, ER-α, ER-Alpha, ER α, ER alpha, ER
Anti-ER alpha Antibody (5U584) is an antibody targeting ER alpha. Anti-ER alpha Antibody (5U584) can be used in ELISA, WB.
Anti-ER alpha Antibody (5U584)
Anti-ER alpha Antibody (5U584)
😃Good
Catalog No. TMAH-00406Alias Nuclear Receptor Subfamily 3 Group A Member 1, NR3A1, estrogen receptor α, estrogen receptor alpha, Estrogen Receptor, Estradiol Receptor, ESR1, ESR, ER-α, ER-Alpha, ER α, ER alpha, ER
Anti-ER alpha Antibody (5U584) is an antibody targeting ER alpha. Anti-ER alpha Antibody (5U584) can be used in ELISA, WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $208 | 7-10 days | |
| 100 μL | $348 | 7-10 days |
Bulk & Custom
Add to Cart
Questions
View MoreContact us for more batch information
Resource Download
Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-ER alpha Antibody (5U584) is an antibody targeting ER alpha. Anti-ER alpha Antibody (5U584) can be used in ELISA, WB. |
| Alias | Nuclear Receptor Subfamily 3 Group A Member 1, NR3A1, estrogen receptor α, estrogen receptor alpha, Estrogen Receptor, Estradiol Receptor, ESR1, ESR, ER-α, ER-Alpha, ER α, ER alpha, ER |
| Ig Type | Rabbit IgG |
| Clone | 5U584 |
| Reactivity | Human, Mouse |
| Verified Activity | Western Blot -Positive WB detected in: NIH/3T3 whole cell lysate, SH-SY5Y whole cell lysate, U-87 whole cell lysate -All lanes: Estrogen Receptor alpha antibody at 1:1000 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 67, 54, 48, 36 kDa -Observed band size: 67 kDa |
| Application | ELISA, WB |
| Recommended Dose | WB:1:500-1:5000. |
| Antibody Type | Monoclonal |
| Subcellular Localization | [Isoform 1]: Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.; Nucleus. Golgi apparatus. Cell membrane. Note=Colocalizes with ZDHHC7 and ZDHHC21 in the Golgi apparatus where most probably palmitoylation occurs. Associated with the plasma membrane when palmitoylated. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3. Involved in activation of NOS3 and endothelial nitric oxide production. Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor. Binds to ERE and inhibits isoform 1. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human Estrogen Receptor alpha |
| Antigen Species | Human |
| Gene ID | 2099 |
| Uniprot ID | |
| Biology Area | Epigenetics and Nuclear Signaling, Neuroscience, Cancer, Signal transduction |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
Sci Citations
Calculator
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy Anti-ER alpha Antibody (5U584) | purchase Anti-ER alpha Antibody (5U584) | Anti-ER alpha Antibody (5U584) cost | order Anti-ER alpha Antibody (5U584)
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.