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PIP4K2A Protein, Human, Recombinant (His)

Catalog No. TMPJ-00978
Synonyms: Diphosphoinositide kinase 2-α, PtdIns(5)P-4-kinase isoform 2-alpha, PIP5KIII, Phosphatidylinositol 5-phosphate 4-kinase type II α, 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha, Phosphatidylinositol 5-phosphate 4-kinase type II alpha, 1-phosphatidylinositol 5-phosphate 4-kinase 2-α, PtdIns(5)P-4-kinase isoform 2-α, PtdIns(4)P-5-kinase B isoform, Diphosphoinositide kinase 2-alpha, PtdIns(4)P-5-kinase C isoform

Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (PIP4K2A) is a member of the phosphatidylinositol-4-phosphate 5-kinase family. It contains 1 PIPK domain and is expressed ubiquitously, with high levels in the brain. It catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). It may exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. It may regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation, negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P. It also involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size.

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PIP4K2A Protein, Human, Recombinant (His)
Pack Size Availability Price/USD Quantity
10 μg 5 days $ 184.00
50 μg 5 days $ 545.00
500 μg 5 days $ 1,900.00
1 mg 5 days $ 2,970.00
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Biological Description
Technical Params
Product Properties
Description Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (PIP4K2A) is a member of the phosphatidylinositol-4-phosphate 5-kinase family. It contains 1 PIPK domain and is expressed ubiquitously, with high levels in the brain. It catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). It may exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. It may regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation, negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P. It also involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size.
Species Human
Expression System Human Cells
Tag C-6His
Accession Number P48426
Synonyms Diphosphoinositide kinase 2-α, PtdIns(5)P-4-kinase isoform 2-alpha, PIP5KIII, Phosphatidylinositol 5-phosphate 4-kinase type II α, 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha, Phosphatidylinositol 5-phosphate 4-kinase type II alpha, 1-phosphatidylinositol 5-phosphate 4-kinase 2-α, PtdIns(5)P-4-kinase isoform 2-α, PtdIns(4)P-5-kinase B isoform, Diphosphoinositide kinase 2-alpha, PtdIns(4)P-5-kinase C isoform
Amino Acid Met1-Thr406
Construction Recombinant Human Phosphatidylinositol 5-phosphate 4-kinase Type-2 Alpha is produced by our Mammalian expression system and the target gene encoding Met1-Thr406 is expressed with a 6His tag at the C-terminus.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 52-58 KDa, reducing conditions
Endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Reconstitution Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
Stability & Storage

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Research Background Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (PIP4K2A) is a member of the phosphatidylinositol-4-phosphate 5-kinase family. It contains 1 PIPK domain and is expressed ubiquitously, with high levels in the brain. It catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). It may exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. It may regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation, negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P. It also involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size.

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Keywords

PIP4K2A Protein, Human, Recombinant (His) Diphosphoinositide kinase 2-α PtdIns(5)P-4-kinase isoform 2-alpha PIP5KIII Phosphatidylinositol 5-phosphate 4-kinase type II α 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha Phosphatidylinositol 5-phosphate 4-kinase type II alpha 1-phosphatidylinositol 5-phosphate 4-kinase 2-α PtdIns(5)P-4-kinase isoform 2-α PtdIns(4)P-5-kinase B isoform Diphosphoinositide kinase 2-alpha PtdIns(4)P-5-kinase C isoform recombinant recombinant-proteins proteins protein

 

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