PIP4K2A Protein, Human, Recombinant (His)

Name: PIP4K2A Protein, Human, Recombinant (His)
Brand: TargetMol
SKU: TMPJ-00978
Price: 112 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: PtdIns(5)P-4-kinase isoform 2-α, PtdIns(5)P-4-kinase isoform 2-alpha, PtdIns(4)P-5-kinase C isoform, PtdIns(4)P-5-kinase B isoform, PIP5KIII, Phosphatidylinositol 5-phosphate 4-kinase type II α, Phosphatidylinositol 5-phosphate 4-kinase type II alpha, Diphosphoinositide kinase 2-α, Diphosphoinositide kinase 2-alpha, 1-phosphatidylinositol 5-phosphate 4-kinase 2-α, 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) Copy Product Info

Synonyms: PtdIns(5)P-4-kinase isoform 2-α, PtdIns(5)P-4-kinase isoform 2-alpha, PtdIns(4)P-5-kinase C isoform, PtdIns(4)P-5-kinase B isoform, PIP5KIII, Phosphatidylinositol 5-phosphate 4-kinase type II α, Phosphatidylinositol 5-phosphate 4-kinase type II alpha, Diphosphoinositide kinase 2-α, Diphosphoinositide kinase 2-alpha, 1-phosphatidylinositol 5-phosphate 4-kinase 2-α, 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha

Catalog No. TMPJ-00978 Copy Product Info

Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (PIP4K2A) is a member of the phosphatidylinositol-4-phosphate 5-kinase family. It contains 1 PIPK domain and is expressed ubiquitously, with high levels in the brain. It catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). It may exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. It may regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation, negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P. It also involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size.

PIP4K2A Protein, Human, Recombinant (His)

Customer service consultation

Pack Size	Price	USA Stock	Global Stock
5 µg	$112	-	In Stock
10 µg	$183	-	In Stock
20 µg	$292	-	In Stock
50 µg	$545	-	In Stock
100 µg	$792	-	In Stock
200 µg	$1,150	35 days	35 days
500 µg	$1,900	35 days	35 days
1 mg	$2,970	35 days	35 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Cart

Add to Quotation

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Batch Information

Select Batch

Purity:Greater than 95% as determined by reducing SDS-PAGE.

Appearance:Lyophilized powder

Color:White

Resource Download

COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (PIP4K2A) is a member of the phosphatidylinositol-4-phosphate 5-kinase family. It contains 1 PIPK domain and is expressed ubiquitously, with high levels in the brain. It catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). It may exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. It may regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation, negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P. It also involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size.
Species	Human
Expression System	HEK293 Cells
Tag	C-6xHis
Accession Number	P48426
Amino Acid	Met1-Thr406
Construction	Met1-Thr406
Protein Purity	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Endotoxin	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM PB, 150 mM NaCl, pH 7.4.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	PtdIns(5)P-4-kinase isoform 2-α, PtdIns(5)P-4-kinase isoform 2-alpha, PtdIns(4)P-5-kinase C isoform, PtdIns(4)P-5-kinase B isoform, PIP5KIII, Phosphatidylinositol 5-phosphate 4-kinase type II α, Phosphatidylinositol 5-phosphate 4-kinase type II alpha, Diphosphoinositide kinase 2-α, Diphosphoinositide kinase 2-alpha, 1-phosphatidylinositol 5-phosphate 4-kinase 2-α, 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha
Research Background	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (PIP4K2A) is a member of the phosphatidylinositol-4-phosphate 5-kinase family. It contains 1 PIPK domain and is expressed ubiquitously, with high levels in the brain. It catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). It may exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. It may regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation, negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P. It also involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size.

Chemical Properties

Molecular Weight

52-58 KDa (reducing condition)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.