Shopping Cart

Your shopping cart is currently empty

Xanthotoxol

Name: Xanthotoxol
Brand: TargetMol
SKU: T4S1659
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T4S1659Cas No. 2009-24-7

Alias Psoralen, 8-Hydroxypsoralene, 8-Hydroxypsoralen, 8-Hydroxyfuranocoumarin

Xanthotoxol (Psoralen) is a biologically active linear furocoumarin, shows strong pharmacological activities as anti-inflammatory, antioxidant, 5-HT antagonistic, and neuroprotective effects.

Xanthotoxol

Copy Product Info

🥰Excellent

Purity: 99.97%

Catalog No. T4S1659Alias Psoralen, 8-Hydroxypsoralene, 8-Hydroxypsoralen, 8-HydroxyfuranocoumarinCas No. 2009-24-7

Xanthotoxol (Psoralen) is a biologically active linear furocoumarin, shows strong pharmacological activities as anti-inflammatory, antioxidant, 5-HT antagonistic, and neuroprotective effects.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$32	In Stock	In Stock
10 mg	$52	In Stock	In Stock
25 mg	$78	In Stock	In Stock
50 mg	$108	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$37	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.97%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HPLC HNMR

Product Introduction

Xanthotoxol AI Summary

Xanthotoxol is a versatile bioactive molecule with a range of properties and effects. In anticancer studies, it shows activity against human HT-29 cells after 72 hours by MTT assay with an IC50 greater than 500,000 nM. It also exhibits anticorpulence activity in mouse 3T3L1 cells, inhibiting lipid droplet accumulation with an IC50 greater than 500,000 nM. Antiviral properties are evident with hepatitis B virus in human MS-G2 cells, inhibiting surface antigen production at various concentrations: 19.8% at 100 µM, 10.5% at 50 µM, and 5.2% at 10 µM. Additionally, it inhibits e-antigen production at rates of 0.7%, 2.7%, and -5.0% respectively. Notably, it exhibits 17.0%, 12.2%, and 7.8% cytotoxicity against MS-G2 cells at those same concentrations via MTT assay. In terms of antioxidant activities, Xanthotoxol effectively scavenges ABTS, DPPH, and galvinoxyl radicals with IC50 values of 10,300 nM, 69,600 nM, and 188,300 nM respectively. The compound also inhibits AAPH-induced linoleic acid lipid peroxidation and soybean LOX, with moderate antioxidant properties showing activity rates from 22.0% to 25.0%. Moreover, it exhibits antibacterial activity against Helicobacter pylori SS1 with a minimum inhibitory concentration (MIC) greater than 50 µg/mL, suggesting a moderate to weak inhibitory effect. It also inhibits chronic active B-cell receptor signaling with a potency of 163.6 nM, secretory acid sphingomyelinase at 25,118.9 nM, and Hepatitis C Virus (HCV) at 1000 nM. Lastly, the compound shows inhibitory activity against the recombinant human BACE1 enzyme with an IC50 value greater than 500,000 nM, and at 500 µM, it achieves 32.8% inhibition after 60 minutes, indicating its potential as a BACE1 inhibitor..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Xanthotoxol (Psoralen) is a biologically active linear furocoumarin, shows strong pharmacological activities as anti-inflammatory, antioxidant, 5-HT antagonistic, and neuroprotective effects.
Synonyms	Psoralen, 8-Hydroxypsoralene, 8-Hydroxypsoralen, 8-Hydroxyfuranocoumarin

Chemical Properties

Molecular Weight	202.16
Formula	C₁₁H₆O₄
Cas No.	2009-24-7
Smiles	Oc1c2occc2cc2ccc(=O)oc12
Relative Density.	1.526g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (296.79 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.89 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.9466 mL	24.7329 mL	49.4658 mL	247.3288 mL
5 mM	0.9893 mL	4.9466 mL	9.8932 mL	49.4658 mL
10 mM	0.4947 mL	2.4733 mL	4.9466 mL	24.7329 mL
20 mM	0.2473 mL	1.2366 mL	2.4733 mL	12.3664 mL
50 mM	0.0989 mL	0.4947 mL	0.9893 mL	4.9466 mL
100 mM	0.0495 mL	0.2473 mL	0.4947 mL	2.4733 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc